摘要
目的观察双侧足三里穴位注射胰激肽原酶治疗糖尿病周围血管病变的临床疗效及对患者踝肱指数(ABI)及血管超声的影响。方法 460例糖尿病周围血管病变患者随机分成观察组和对照组,每组230例。观察组给予胰激肽原酶双侧足三里穴位注射治疗,对照组施行胰激肽原酶肌肉注射治疗。观察两组治疗前后踝肱指数及血管超声等血管病变指标和凝血指标水平变化,统计两组患者治疗期间不良反应发生情况,并比较临床疗效。结果观察组总有效率为91.3%,高于对照组的85.2%(P<0.05)。治疗后两组患者ABI以及足背动脉血流量均明显升高P<0.01),且观察组各指标均高于对照组(P<0.05,P<0.01)。两组治疗后腘动脉狭窄程度显著减轻,收缩期最大血流速度增加程度以及舒张末期血流速度减慢程度均明显缓解(P<0.05,P<0.01),且组间比较,差异有统计学意义(P<0.05,P<0.01)。治疗后两组患者PT和FIB均呈明显的降低状态,APTT明显升高(P<0.01),且组间比较,差异有统计学意义(P<0.01)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论胰激肽原酶双侧足三里穴位注射治疗可有效改善糖尿病周围血管病变患者的临床症状,并能有效改善其血管病变指标水平,效果确切。
Objective To observe the clinical efficacy of acupoint injection at bilateral Zusanli(ST36)with pancreatic kininogenase in treating diabetic peripheral vascular disease(DPVD)and its effect on ankle-brachial index(ABI)and vascular ultrasound.Method A total of 460 DPVD patients were randomized into an observation group and a control group,with 230 cases in each group.The observation group was intervened by acupoint injection at bilateral Zusanli(ST36)with pancreatic kininogenase,while the control group was given pancreatic kininogenase via intramuscular injection.The ABI,vascular ultrasound and blood coagulation indexes were observed before and after the treatment;adverse reactions occurred during the intervention were evaluated;the clinical efficacies were also compared.Result The total effective rate was 91.3%in the observation group,higher than 85.2%in the control group(P<0.05).The ABI and blood flow of dorsal artery of foot increased significantly after the treatment in both groups(P<0.01),and the values in the observation group were significantly higher than those in the control group(P<0.05,P<0.01).After the treatment,the popliteal artery stenosis was improved in both groups,and the increase in the peak blood flow velocity during systole and the decrease in the blood flow velocity at the end of diastole were also improved(P<0.05,P<0.01);the between-group differences were statistically significant(P<0.05,P<0.01).The prothrombin time(PT)and fibrinogen(FIB)dropped,and the activated partial thromboplastin time(APTT)increased significantly after the treatment in both groups(P<0.01),and the between-group differences were statistically significant(P<0.01).There was no significant difference in the occurrence rate of adverse reactions between the two groups(P>0.05).Conclusion Acupoint injection at bilateral Zusanli(ST36)with pancreatic kininogenase can effectively improve the clinical symptoms in DPVD and the vascular indexes,and thus the efficacy is valid.
作者
赵秋波
徐凤梅
李杰玉
ZHAO Qiu-bo;XU Feng-mei;LI Jie-yu(General Hospital of Hebi Coal Industry(Group)Company,Hebi 458000,China;Nanyang City Center Hospital,Nanyang 473000,China)
出处
《上海针灸杂志》
2018年第9期992-996,共5页
Shanghai Journal of Acupuncture and Moxibustion
关键词
糖尿病血管病
糖尿病并发症
胰激肽原酶
水针
穴
足三里
Diabetic Angiopathies
Diabetes Complications
Pancreatic kininogenase
Hydroacupuncture
Point,Zusanli(ST36)
