期刊文献+

晚期糖基化终末产物与心血管疾病关系的研究进展 被引量:11

下载PDF
导出
摘要 晚期糖基化终末产物(AGEs)是一组以蛋白质、脂肪及核酸的氨基和还原糖为原料发生非酶促糖基化反应生成的稳定共价化合物。AGEs堆积与诸多疾病尤其是心血管疾病的发生、发展紧密相关。AGEs通过诱导冠状动脉炎症、降低冠状动脉顺应性、增加冠脉脂质堆积、加重心肌损伤、促进心肌纤维化等多种机制造成冠状动脉内皮及心肌细胞的结构改变和功能紊乱,导致心血管疾病的发生。
作者 陈其谋
出处 《山东医药》 CAS 2018年第33期94-96,共3页 Shandong Medical Journal
  • 相关文献

参考文献3

二级参考文献47

  • 1江曼丽.糖基化作用与糖尿病慢性并发症[J].国外医学(内分泌学分册),1997,17(1):32-35. 被引量:56
  • 2Speidl WS, Graf S, Hornykewycz S, et al. High-sensitivity C-reactive protein in the prediction of coronary events in patients with premature coronary artery disease [ J ]. Am Heart J, 2002,144 ( 3 ) : 449-455.
  • 3Hou FF, Owen WF Jr. Beta 2-microglobulin amyloidosis:role of monocytes/macrophages[J]. Curr Opin Nephrol Hypertens, 2002, 11 (4) :417-421.
  • 4Kalousova M, Zima T, Tesar V, et al. Advanced glycation end products and advanced oxidation protein products in hemodialyzed patients [I]. Blood Purif, 2002,20(6) :531-536.
  • 5Ridker PM. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: Moving an inflammatory hypothesis toward consensus. J Am Coli Cardiol2007; 49: 2129-38.
  • 6Bisoendial RJ, Boekholdt SM, Vergeer M, Stroes ES, Kastelein JJ. C-reactive protein is a mediator of cardiovascular disease. Eur Heart J 2010; 31: 2087 -91.
  • 7Grad E, Danenberg HD. C-reactive protein and atherothrombosis: Cause or effect? Blood Rev 2013; 27: 23-9.
  • 8Sundgren NC, Zhu W, Yuhanna IS, Chambliss KL, Ahmed M, Tanigaki K, et al. Coupling of Fcy receptor I to Fcy receptor lib by src kinase mediates c-reactive protein impairment of endothelial function. Circ Res 2011; 109: 1132-40.
  • 9Raaz-Schrauder D, Ekici AB, Klinghammer L, Stumpf C, Achenbach S, Herrmann M, et al. The proinflammatory effect of c-reactive protein on human endothelial cells depends on the Fcy lIa genotype. Thromb Res 2014; 133: 426-32.
  • 10Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011; 473: 317- 25.

共引文献3

同被引文献106

引证文献11

二级引证文献39

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部