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广东部分地区人群HPV持续感染影响因素研究 被引量:11

Influencing Factors of HPV Persistent Infection in Some Area of Guangdong Province
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摘要 【目的】探讨在广东地区影响人乳头瘤病毒(HPV)持续感染的环境因素。【方法】对14 594名妇女进行HPV基因分型初筛,1年后采用方便抽样的方法重新取样检测,以两次检测结果确定持续感染组,对照组则由HPV初筛阳性转阴性和第1或第2次HPV筛查结果为阴性的人群组成。通过流行病学调查问卷收集研究对象基本信息,分析环境因素与HPV持续感染之间的相关性。【结果】首次筛查HPV阳性人数为1 050人,阳性率为7.21%(1 050/14 559)。1年后复检,共309名研究对象存在HPV持续感染,检测出16种HPV持续感染亚型,持续感染排在前4位的HPV亚型分别是HPV52(28.2%)、HPV58(18.8%)、HPV16(17.2%)、HPV18(11.0%)。非条件Logistic回归分析结果显示:怀孕次数(OR=2.10,95%CI=1.64~2.70,P=0.000)、初孕年龄(OR=1.39,95%CI=1.13~1.71,P=0.002)和同房前后清洗习惯(OR=0.48,95%CI=0.38~0.60,P=0.000)是HPV持续感染的独立影响因素。【结论】怀孕次数多和初孕年龄大是发生HPV持续感染的危险因素,同房前后清洗习惯能够降低HPV持续感染风险。 【Objective】To investigate the environmental factors that may affect the persistent infection of human papil-lomavirus(HPV)in Guangdong Province.【Methods】A total of 14594 women were screened for HPV genotyping.One year later,convenience sampling method was used to choose the subjects to screen for HPV genotyping as well.Consequently,subjects were defined as HPV persistent infection group according to the results of above two screenings.The control group consisted of people who were screened initially positive to negative,and negative in the first or second HPV screening.Epi-demiological questionnaire was used to collect the basic information of the subjects to analyze the correlation between envi-ronmental factors and HPV persistent infection.【Results】A total of 1 050 people were screened with HPV-positive initial-ly,with positive rate of 7.21%(1050/14559).After one year follow-up study,a total of 309 subjects had HPV persistent infection.A total of 16 subtypes of HPV persistent infection were detected.The top four HPV subtypes were HPV52(28.2%),HPV58(18.8%),HPV16(17.2%)and HPV18(11.0%),respectively.Logistic regression analysis showed that the times of pregnancy(OR=2.10,95%CI=1.64~2.70,P=0.000),first gestational age(OR=1.39,95%CI=1.13~1.71,P=0.002),and sexual hygiene(OR=0.48,95%CI=0.38-0.60,P=0.000)were the independent influential factors of HPV persistent infection.【Conclusion】The increasing times of pregnancy and first gestational age increasing both were the risk factors of HPV persistent infection.Sexual hygiene could reduce the risk of HPV persistent infection.
作者 张蕴蕊 黄伟煌 井立鹏 荆春霞 ZHANG Yun-rui;HUANG Wei-huang;JING Li-peng;JING Chun-xia(Quality and Safety Management Office,The First Affiliated Hospital of Jinan University,Guangzhou 510632,China;Department of Epidemiology,School of Medicine,Jinan University,Guangzhou 510632,China)
出处 《中山大学学报(医学版)》 CAS CSCD 北大核心 2018年第5期766-770,共5页 Journal of Sun Yat-Sen University:Medical Sciences
基金 国家自然科学基金(81541070) 广东省自然科学基金(1614050000600)
关键词 人乳头瘤病毒 持续感染 影响因素 human papillomavirus persistent infection influence factors
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  • 1吴瑞芳,刘植华,周庆芝,乌兰娜,王倩,李晴,李霓,刘志红,石菊芳,李瑞珍,张长淮,周艳秋,刘彬,翁雷明,乔友林.深圳女性生殖道人乳头瘤病毒感染与子宫颈上皮内瘤样病变现患率调查及子宫颈癌筛查方法的评价[J].中国医学科学院学报,2010,32(1):90-95. 被引量:57
  • 2林广玲,翁建盛,林小荣,陈林兴,林少晖,林美珊.粤东地区妇女下生殖道HPV亚型的基因芯片检测与分析[J].江西医学检验,2006,24(4):303-305. 被引量:40
  • 3Jemal A,Bray F,Center M M,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
  • 4Parkin DM,Bray F.Chapter 2:The burden of HPV-related cancers[J].Vaccine,2006,31(24):11-25.
  • 5Bosch FX,Burchell AN,Schiffman M,et al.Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia[J].Vaccine,2008,19(26):64.
  • 6Naucler P,Ryd W,Tornberg S,et al.Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening[J].J Natl Cancer Inst,2009,101(2):88-99.
  • 7Weinberg CR.HPV screening for cervical cancer in rural India[J].N Engl J Med,2009,361(3):305-306.
  • 8Li C,Wu M,Wang J,et al.A population-based study on the risks of cervical lesion and human papillomavirus infection among women in Beijing,People's Republic of China[J].Cancer Epidemiol Biomarkers Prev,2010,19(10):2655-2664.
  • 9Chen Z,Meng W,Du R,et al.Genotype distribution and the relative risk factors for human papillomavirus in Urumqi,China[J].Exp Ther Med,2013,6(1):85-90.
  • 10Molano M,Posso H,Weiderpass E,et al.Prevalence and determinants of HPV infection among Colombian women with normal cytology[J].Br J Cancer,2002,87(3):324-333.

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