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心脏瓣膜置换术中凝血功能变化及对华法林出血不良反应的监测 被引量:1

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摘要 目的分析心脏瓣膜置换术患者活化部分凝血酶时间(APTT)、凝血酶时间(TT)等凝血功能指标的变化情况,以及对华法林出血不良反应的监控。方法选取该院2014年12月至2017年12月接受心脏瓣膜置换术的120例患者设为观察组,选取同期体检的年龄、性别匹配健康人群120例设为对照组。检测两组人群APTT、TT、凝血酶原时间(PT)、纤维原蛋白(FIB)水平。结果观察组术后PT、TT和APTT明显长于对照组,FIB高于对照组。观察组随访3个月,出血50例(41.7%),出血组APTT延长率为56.0%,TT延长率为36.0%,PT延长率为64.0%。不出血组APTT延长率为37.1%,TT延长率为28.6%,PT延长率为41.4%。结论心脏瓣膜置换术后患者的APTT和P T指标可用于评估华法林抗凝效果。
出处 《中国乡村医药》 2018年第20期44-45,共2页
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