摘要
目的探讨M型抗磷脂酶A2受体抗体在成人特发性膜性肾病(IMN)诊断、病情判断方面的作用。方法选取2016年10月至2017年10月我院经肾活检确诊为肾小球疾病51例为研究对象,其中IMN17例,IgA肾病20例,系膜增生性肾炎3例,微小病变型肾病10例,局灶节段性肾小球硬化1例,应用间接免疫荧光法检测血清M型抗磷脂酶A2受体抗体,并比较IMN抗体阳性及阴性组之间的24 h尿蛋白定量、人血白蛋白水平及大量蛋白尿、低蛋白血症发生率。结果 17例IMN患者中13例血清M型磷脂酶A2受体抗体阳性,阳性率为76.4%,其他肾小球疾病均阴性,IMN患者中血清抗体阳性和阴性组24 h尿蛋白定量、人血白蛋白水平分布及大量蛋白尿及低蛋白血症发生率差异显著(P <0.05)。结论血清M型抗磷脂酶A2受体抗体是IMN诊断及病情判断的一项重要指标。
Objective To explore the role of M type anti-phospholipase A2 receptor antibody in the diagnosis and diagnosis of adult idiopathic membranous nephropathy(IMN).Methods From October 2016 to October 2017,the diagnosis of renal biopsy in our hospital was confirmed as the study object,including 20 cases of IMN17 and IgA nephropathy.Mesangial proliferative glomerulonephritis(3 cases),tiny lesions in 10 cases,cast nephropathy focal segmental glomerular sclerosis in 1 case,the application of indirect immunofluorescence method to detect serum M type of phospholipase A2 receptor antibody,and compare the IMN antibody positive and negative groups between the 24 h urine protein quantitative,human blood albumin levels and incidence of massive proteinuria,hypoalbuminemia.Results 17 cases of 13 patients with IMN M type serum phospholipase A2 receptor antibody positive,positive rate was 76.4%,other glomerular disease were negative,IMN patients serum antibody positive and negative groups in 24 hours urine protein,blood albumin levels distribution and quantitative of proteinuria and hypoalbuminemia was significant difference(P<0.05).Conclusion The serum M type anti-phospholipid enzyme A2 receptor antibody is an important indicator of IMN diagnosis and condition.
作者
成龙
CHENG Long(Department of Nephrology,Erdos City Central Hospital,Erdos 017000,China)
出处
《中国医药指南》
2018年第28期13-14,共2页
Guide of China Medicine
