摘要
目的探讨寡转移性前列腺癌根治术联合内分泌治疗较单一内分泌治疗能否使患者受益及寡转移性前列腺癌患者行根治术的安全性。方法选择2014年1月～2016年1月至我院泌尿外科就诊的前列腺癌患者,回顾分析患者术中、术后并发症情况及激素依赖性生存期和3年癌症特异性生存率。结果手术患者术中均未中转开腹,平均手术时间180min,平均术中出血量370ml,术后3例患者出现尿漏,5例患者出现淋巴漏,6例患者出现低蛋白血症,通过术后引流管引流,输血浆补蛋白等措施,患者均自行恢复。前列腺癌根治术联合内分泌治疗患者的激素依赖性生存期平均为26.82个月,单一内分泌治疗患者的激素依赖性生存期平均为20.45个月,差异具有统计学意义(P<0.01),3年癌症特异性生存率均为100%。结论腹腔镜下前列腺癌根治术联合内分泌治疗较单一内分泌治疗可提高患者激素依赖性生存期,使患者受益,且手术难度较T1、T2期前列腺癌患者并未明显增加,术中、术后未出现严重并发症,寡转移性前列腺癌患者行前列腺癌根治术是可行的。
Objective To explore whether the radical surgery of prostate cancer with endocrine therapy for oligometastatic prostate cancer benefit the patients and the safety of the radical surgery in patients with oligometastatic prostate cancer.Methods The patients who were admitted to our hospital for urological surgery with prostate cancer were collected from Jan 2014 to Jan 2016.The postoperative complications and hormone dependent survival and 3 years of cancer-specific survival were retrospectively analyzed.Results All patients didn't transfer laparotomy,the average operation time was 180min,the average intraoperative blood loss of 370ml,3 cases of urinary leakage,5 patients of lymphatic leakage,6 patients of hypoalbuminemia.Patients recovered on its own through postoperative drainage tube drainage and losing plasma protein supplement.The hormone-dependent survival time of patients treated with radical surgery and endocrine therapy was 26.82 months on average.The hormone-dependent survival time of patients treated with single endocrine therapy was 20.45 months on average.The difference was statistically significant(P<0.01).Cancer specific survival rates were 100%at 3 years.Conclusion Compared with single endocrine therapy,laparoscopic radical surgery with endocrine therapy can improve the prostate cancer patients survival,benefit the patients,and the operation difficulty don't significantly increase compare with T1,T2 stage prostate cancer,no serious complications occurred.Radical surgery of prostate cancer is feasible for patients with oligometastatic prostate cancer.
作者
倪刚
李庆文
陈志军
郭园园
Ni Gang;Li Qingwen;Chen Zhijun(Department of Urology,t he First Affiliated Hospital of Bengbu Medical College,Bengbu 233000)
出处
《中国现代医药杂志》
2018年第10期27-30,共4页
Modern Medicine Journal of China
关键词
寡转移性前列腺癌
前列腺癌根治术
内分泌治疗
减瘤手术
Oligometastatic prostate cancer
Radical surgery of prostate cancer
Endocrine therapy
Cytoreductive surgery
