摘要
目的探讨白参健胃方联合常规西药三联疗法在胃溃疡治疗中应用价值评估。方法消化内科诊治的120例胃溃疡患者依据不同治疗方法分为2组,对照组采用常规西药三联疗法(克拉霉素+阿莫西林+奥美拉唑),观察组采用白参健胃方联合常规西药三联疗法治疗,治疗后4周比较2组患者的临床疗效、症状改善情况、H. pylori根除率及溃疡面愈合率、各项血清因子水平变化。结果观察组治疗有效率为96. 67%明显高于对照组的75. 00%,差异有统计学意义(P <0. 05);观察组治疗后泛酸、嗳气、嘈杂、胃脘疼痛、胃脘胀满、口干味苦、大便不调等中医证候积分明显低于对照组,差异有统计学意义(P <0. 05);观察组H. pylori根除率为86. 67%、溃疡面愈合率为95. 00%,明显高于对照组的65. 00%、71. 67%,差异有统计学意义(P <0. 05);观察组治疗后GAS、SS、MTL、PGE2、TFF2、SOD水平与对照组相比明显改善,差异有统计学意义(P <0. 05)。结论白参健胃方联合常规西药三联疗法在胃溃疡临床治疗中应用效果显著,能有效缓解各项症状,促进溃疡面的愈合,抑制H. pylori,调节胃肠道激素水平,减轻胃黏膜炎性反应,具有积极的临床意义。
Objective To investigate the application value assessment of Baishenjianwei prescription combined with traditional western medicine triple therapy in treatment of gastric ulcer.Methods A total of 120 patients with gastric ulcer who were treated in gastroenterology department of our hospital from october 2016 to october 2017 were divided into two groups according to the different therapeutic methods.The patients in control group were treated by conventional western medicine triple therapy(clarithromycin+amoxicillin+omeprazole),the patients in observation group,on the basis of control group,were treated by Baishenjianwei prescription.After 4-week treatment the clinical curative effects,improvement status of symptoms,the eliminate rate of HP and healing rate of anabrosis,the changes of several serum factors levels were observed and compared between the two groups.Results The effective rate in observation group was significantly higher than that in control group(96.67%vs 75%,P<0.05).After treatment the scores of TCM syndrome including pantothenic acid,belching,noisy,pain of gastral cavity,turgor of gastral cavity,dry mouth and bitter taste,defecate disorder in observation group were significantly lower than those in control group(P<0.05).The eliminate rate of HP and healing rate of anabrosis in observation group were significantly higher than those in control group(86.67%vs 65%,95%vs 71.67%,P<0.05).After treatment,the levels of GAS,SS,MTL,PGE2,TFF2 and SOD in observation group were significantly improved,as compared with those in control group(P<0.05).Conclusion Baishenjianwei prescription combined with traditional western medicine triple therapy has obvious therapeutic effects on gastric ulcer,which can effectively alleviate symptoms of patients,promote healing of the ulcer surface,inhibit HP and regulate the levels of gastrointestinal hormone,reduce the gastric mucosa inflammation,which has positive clinical significance.
作者
陈永梅
朱淑娜
王凤格
潘俊霞
CHEN Yongmei;ZHU Shuna;WANG Fengge;PAN Junxia(Laiyuan County Hospital,Hebei,Laiyuan 074300,China)
出处
《河北医药》
CAS
2018年第21期3257-3260,共4页
Hebei Medical Journal
关键词
胃溃疡
白参健胃方
常规西药三联疗法
治疗结果
gastric ulcer
Baishenjianwei prescription
routine western medicine triple therapy
treatment outcome
