摘要
目的探讨脾多肽辅助甘草锌颗粒对小儿慢性腹泻血锌水平以及免疫功能的影响。方法选取2014年3月至2016年4月于我院就诊的小儿慢性腹泻患儿110例,采用随机数表法分为实验组(n=58)和对照组(n=52)。对照组给予甘草锌颗粒治疗,实验组在此基础上给予脾多肽辅助治疗。对比治疗后临床效果,记录患儿治疗前、治疗后血锌水平、免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)、免疫球蛋白G(Ig G)、CD3+、CD4+、CD8+、CD4+/CD8+变化。结果治疗后,实验组总有效率93. 11%高于对照组80. 77%(P <0. 05);治疗后,两组患儿Ig A、Ig M、Ig G、血锌表达水平均高于治疗前,但实验组以上指标明显高于对照组(P <0. 05);治疗后,两组患儿CD3+、CD4+、CD4+/CD8+均高于治疗前,实验组高于对照组(P <0. 05);治疗后,两组患儿CD8+均低于治疗前,实验组低于对照组(P <0. 05)。结论给予小儿慢性腹泻患儿脾多肽+甘草锌颗粒治疗,可提高患儿血锌水平,提高患儿免疫功能,效果显著,值得临床推广使用。
Objective:To investigate the effect of spleen peptide assisted Licorice Zinc Granules on blood zinc level and immune function in children with chronic diarrhea.Methods:110 cases from March 2014 to April 2016 in our hospital for treatment of children with chronic diarrhea were divided into experimental group and control group(n=52),using a random number table method(n=58).The control group was treated with Licorice Zinc Granules,and on this basis,the experimental group was also given the adjuvant therapy of spleen polypeptide.Clinical effects were compared after treatment.Serum zinc level,immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG),CD3+CD4+,CD8+and CD4+/CD8+were recorded before and after treatment.Results:After treatment,the total efficiency of experimental group was 93.11%.Which was higher than that of the control group 80.77%(P<0.05);after treatment,the expression levels of IgA,IgM,IgG and blood zinc in the two groups were higher than those before the treatment,but the index above in the experimental group was significantly higher than that of the control group(P<0.05).After the treatment,the two groups of children CD3+,CD4+,CD4+/CD8+were higher than those before the treatment,and the experimental group was higher than the control group(P<0.05),and the two groups of children were lower after the treatment than before.The experimental group was lower than the control group(P<0.05).Conclusion:The treatment of children with chronic diarrhea with spleen polypeptide plus Licorice Zinc Granules can improve the level of blood zinc and improve the immune function of children,which is worthy of clinical promotion.
作者
崔卫国
崔圣莹
CUI Wei-guo;CUI Sheng-ying(Taian City Maternal and Child Health Hospital,Taian 271000,China;Taishan Medical University,Taian 271016,China)
出处
《泰山医学院学报》
CAS
2018年第11期1238-1240,共3页
Journal of Taishan Medical College
关键词
小儿慢性腹泻
血锌
脾多肽
甘草锌颗粒
chronic diarrhea in children
blood zinc
spleen polypeptide
Licorice Zinc Granules
