摘要
目的探讨全身炎症反应标志物格拉斯哥预后评分(m GPS)和中性粒细胞/淋巴细胞比值(NLR)在骨肉瘤预后评估中的作用。方法回顾性收集从2008年1月1日至2016年12月31日在我院经组织学病理诊断为骨肉瘤的103例患者资料。分析NLR和mGPS在各临床病理特征组间有无显著差异。Cox回归单因素和多因素分析研究独立预后因子。描绘列线图并采用c-index评价预测精确度。结果 NLR在临床病理特征各组间均无显著差异,性别(P=0.039)、年龄(P=0.000)、肿瘤部位(P=0.030)与mGPS显著相关。肿瘤部位(P=0.023)、初诊时有无转移(P=0.000)、NLR(P=0.011)和mGPS(P=0.007)是骨肉瘤患者总生存期(OS)的独立预后因子,而初诊时有无转移(P=0.029)、NLR(P=0.032)和mGPS(P=0.014)是无事件生存期(EFS)的独立风险因子。列线图显示这个预后预测模型对骨肉瘤的预测准确度较好,OS和EFS的c-index值分别为0.689和0.685。结论 mGPS和NLR均可有效预测骨肉瘤患者的预后。两者在骨肉瘤预后评估中应用价值差距不大。
Objective To investigate the role of the modified Glasgow prognostic score(mGPS)and neutro-phil lymphocyte ratio(NLR)in evaluating the prognosis of patients with osteosarcoma.Mehtods One hundred and three patients with osteosarcoma diagnosed by histology in our hospital from January 1,2008 to December 31,2016 were enrolled in this retrospective study.The values of NLR and mGPS catagorized by different clinical param-eters were compaired.Univariate and multivariate analyses were performed to evaluate the overall survival(OS)and event-free survival(EFS).Nomograms were established to predict the prognosis of osteosarcoma.Results There was no difference of NLR level in paients catagorized by different clinicopathological features.However,there were significant correlations between sex(P=0.039),age(P=0.000),tumor site(P=0.030)and mGPS.In multivariate analysis,tumor site(P=0.023),metastasis(P=0.000),NLR(P=0.011)and mGPS(P=0.007)were independent prognostic factors for OS,while metastasis(P=0.029),NLR(P=0.032)and mGPS(P=0.014)were independent predictors for EFS.The Harrell′s c-index for OS and EFS prediction was 0.689 and 0.685,respectively.Thus the nomogram based on NLR and mGPS could be used as an accurate prognostic prediction for patients with osteosarcoma.Conclusion mGPS and NLR have similar clinical values and both of them can accu-rately predict the prognosis of osteosarcoma.
作者
黄振华
杨晨
罗宇玲
邓琼
戎晓祥
HUANG Zhenhua;YANG Chen;LUO Yuling;DENG Qiong;RONG Xiaoxiang(Department of Oncology,Nanfang Hospi.tal,Southern Medical University,Guangzhou 510515,China)
出处
《实用医学杂志》
CAS
北大核心
2018年第20期3410-3414,共5页
The Journal of Practical Medicine
基金
大学生创新创业训练计划项目(编号:201712121041)
