摘要
非编码RNA指不编码蛋白质的RNA,在生物体的生命活动中发挥着极广泛的调控作用。甲基化是从基因组层面研究RNA转录调控的重要领域,其中microRNA和lncRNA甲基化异常可能是影响肝癌发生发展的关键信号。
Non-coding RNAs(ncRNAs)refer to the RNAs that don't encode proteins,while play an important role in the life activities of organisms.Methylation is the significant part of RNA transcription based on genome.The abnormal methylation of microRNA and lncRNA may be the key signals to influence the occurrence and development of hepatocellular carcinoma(HCC).In this paper,the implication of non-coding RNA(microRNA and lncRNA)methylation in the development of HCC in recent years is reviewed.
作者
刘晓霓
刘秀红
陈德喜
Liu Xiaoni;Liu Xiuhong;Chen Dexi(Institute of Hepatology,You'an Hospital,Capital Medical University,Beijing 100069)
出处
《实用肝脏病杂志》
CAS
2018年第6期991-994,共4页
Journal of Practical Hepatology
基金
国家重大传染病防治协同创新项目(编号:2011协同创新中心)
北京市卫生系统高层次卫生技术人才培养资助项目(编号:2015-3-101)
北京市肝病研究所所内基金(编号:BJIH-01712)
北京市市属医学科研院所公益发展改革试点项目(编号:京医研2016-2)
