摘要
目的探讨Snail蛋白在肝内胆管癌患者中的表达及其意义。方法选取2011年3月～2016年2月在运城市中心医院就诊的72例肝内胆管癌患者,采用免疫组织化学法检测获得的患者组织,观察患者癌组织及癌旁组织Snail蛋白的表达情况、Snail蛋白的表达与临床病理因素的关系以及多因素分析患者总存活率及总复发率情况。结果癌组织的免疫组化评分为(2.8±0.8)分,明显高于癌旁组织的(0.9±0.8)分(P<0.05)。癌组织的Snail蛋白高表达率为45.8%,明显高于癌旁组织的16.7%(P<0.05)。不同表达的Snail蛋白之间的TNM分期、微血管是否侵犯及有无复发比较,差异有统计学意义(P<0.05)。多因素分析显示,微血管是否侵犯及Snail蛋白的高表达或低表达的总存活率及总复发率差异有统计学意义(P<0.05)。结论肝内胆管癌患者癌组织中Snail蛋白的表达要高于癌旁组织,Snail蛋白的表达可作为评价肝内胆管癌患者预后的指标。
Objective To explore the expression and significance of Snail protein in patients with intrahepatic cholangiocarcinoma.Methods A total of 72 patients with intrahepatic cholangiocarcinoma from March 2011 to February 2016 in Center Hospital of Yuncheng City were selected as the research object.Immunohistochemistry was used to detect the patient′s tissues.The expression of Snail protein in the cancer tissues and adjacent tissues,the relationship between the expression of Snail protein and the clinicopathological factors,and the total survival rate and the total recurrence rate of the patients were observed.Results The immunohistochemical score of the tissue was(2.8±0.8)points,which was significantly higher than that of the adjacent tissues([0.9±0.8]points)(P<0.05).The high expression rate of Snail protein in cancer tissues was 45.8%,which was significantly higher than that in adjacent tissues(16.7%)(P<0.05).There were significant differences in TNM staging,microvascular invasion and recurrence between different Snail protein(P<0.05).Multivariate analysis showed that there was a significant difference in the overall survival rate and total recurrence rate of microvessels and the high expression or low expression of Snail protein(P<0.05).Conclusion The expression of Snail protein in the cancer tissues of the patients with intrahepatic cholangiocarcinoma is higher than that in the adjacent tissues,and the expression of Snail protein can be used as an indicator of the prognosis of the patients with intrahepatic cholangiocarcinoma.
作者
朱萌
孙武刚
ZHU Meng;SUN Wu-gang(Teaching and Research Department of Pathology,Yuncheng Vocational Nusing College,Shanxi Province,Yuncheng 044000,China;Department of Pathology,Central Hospital of Yuncheng City in Shanxi Province,Yuncheng 044000,China)
出处
《中国当代医药》
2018年第30期20-22,26,共4页
China Modern Medicine
关键词
免疫组织化学
肝内胆管癌
癌组织
癌旁组织
SNAIL蛋白
Immunohistochemistry
Intrahepatic cholangiocarcinoma
Carcinoma tissue
Precancerous tissue
Snail protein
