摘要
目的探讨不同麻醉方法对宫颈癌手术患者免疫功能的影响。方法选取120例宫颈癌患者,采用数字随机表法分为实验组(硬膜外复合全身麻醉)与对照组(单纯全身麻醉),各60例。对比分析2组患者行不同麻醉方法的免疫功能指标、应激指标与手术指标。结果与同组麻醉前比较,2组患者麻醉后2 h、术后1 d、术后3 d的、对照组术后7 d的NK细胞、CD3+、CD4+、CD8+、CD4+/CD8+水平均降低; 2组患者麻醉后2 h、术后1 d、术后3 d的皮质醇、TNF-α、IL-6水平较麻醉前,差异均有统计学意义(P <0. 05)。与实验组同期比较,对照组麻醉后2 h、术后1 d、术后3 d的NK细胞、CD3+、CD4+、CD8+、CD4+/CD8+水平较低;术后7 d的CD4+、CD8+水平明显较低;麻醉后2 h、术后1d、术后3 d的皮质醇、TNF-α、IL-6与实验组同期比,差异均有统计学意义(P <0. 05)。实验组的手术指标明显优于对照组,但差异无统计学意义(P> 0. 05)。结论对于行手术治疗的宫颈癌患者,相比单纯全身麻醉,硬膜外复合全身麻醉能够更加有效地减缓患者免疫功能的抑制,从而改善患者预后与生活质量。
Objective To dicuss the effect of different anesthesia methods on immune function in patients with cervical cancer.Methods 120 patients with cervical cancer were randomly selected and divided into the experimental group(epidural combined general anesthesia)and the control group(simple general anesthesia),60 cases in each.The immune function index,stress index and operation index of the 2 groups were analyzed.Results Compared with the same group before anesthesia,the levels of NK cells,CD3+,CD4+,CD8+,CD4+/CD8+in the control group at 2 h after anesthesia,at 1 day,3 day after operation and 7 d after operation in the control group decreased.The levels of cortisol,TNF-αand IL-6 in the patients were significantly different at 2 h after anesthesia and at 1 day and 3 days after operation compared with before anesthesia(P<0.05).Compared with the experimental group over the same period,the levels of NK cells CD3+,CD4+,CD8+,CD4+/CD8+in the control group were lower at 2 h after anesthesia,at 1day and 3 day after operation,and the levels of CD4+and CD8+were significantly lower at 7 days after operation,the levels of cortisol,TNF-αand IL-6 at 2 h after anesthesia,at 1 day and 3 days after operation,the difference was statistically significant(P<0.05).The operative index of the experimental group was significantly better than that of the control group,but the difference was not statistically significant(P>0.05).Conclusion For patients with cervical cancer who underwent surgery,combined with general anesthesia,epidural combined general anesthesia can be more effective in slowing the suppression of immune function in patients,thus improving the prognosis and quality of life of patients.
作者
陈敬锋
陈磊
余玮
简国庆
陈燕
CHEN Jingfeng;CHEN Lei;YU Wei(Qianxi'nan Buyei and Miao Autonomous Prefecture People's Hospital of Guizhou,Xingyi,562400)
出处
《实用癌症杂志》
2018年第11期1809-1811,1822,共4页
The Practical Journal of Cancer
基金
2015年黔西南布依族苗族自治州科技计划项目(编号:2015-1-14)
关键词
麻醉
宫颈癌
免疫功能
Anesthesia
Cervical cancer
Immune function
