摘要
目的:探讨老年中重度牙周炎伴2型糖尿病患者牙周基础治疗后牙周感染控制疗效、全唾液中基质金属蛋白酶(MMP)-8水平变化及临床意义。方法:纳入老年中重度牙周炎伴2型糖尿病患者22例为实验组,单纯老年中重度牙周炎患者18例为对照组,进行全口牙周基础治疗。分别于基础治疗前、后3个月检测两组患者临床牙周指标,全唾液中MMP-8含量。结果:基础治疗前两组间PD、PD>5mm百分比、BOP及MMP-8水平比较无明显差异(P>0.05)。基础治疗后3个月两组PD、PD>5mm百分比、BOP及MMP-8水平与基线水平相比均有下降,差异具有统计学意义(P<0.05);两组间PD、PD>5mm百分比、BOP比较无明显差异(P>0.05);实验组MMP-8水平较对照组MMP-8水平相比下降不明显,差异有统计学意(P<0.05)。实验组患者牙周基础治疗后3个月菌斑百分率<20%,全口BOP(+)百分比22.7%,PD>5mm百分比13.6%。结论:牙周基础治疗可以改善老年中重度牙周炎伴T2DM患者的牙周临床指标,降低全唾液中MMP-8水平,牙周感染控制较满意。与单纯老年中重度牙周炎患者相比较,老年中重度牙周炎伴T2DM患者行牙周基础治疗后炎症控制的效果差。
Objective:To investigate the effect of periodontal initial therapy on periodontal infection control,the changes in the level of MMP-8 in whole saliva and its clinical significance in elderly patients with moderate to advanced periodontitis with type2diabetes.Methods:22 cases of elderly patients with moderate to severe periodontitis with type 2 diabetes were included in the experimental group,and 18 of the elderly patients with moderate and severe periodontitis were treated as the control group,and the whole periodontitis was treated with periodontal initial therapy.The clinical periodontal index and MMP-8 content in the whole saliva of two groups were detected before and 3 months after the periodontal initial therapy.Results:There was no significant difference in the levels of PD,PD>5 mm,BOP,and MMP-8 between two groups before therapy(P>0.05).The PD,PD>5 mm,BOP,and MMP-8 levels of two groups were significantly lower than those of baseline at 3 months after therapy,and the difference was statistically significant(P<0.05).There was no significant difference in the PD,PD>5 mm,and BOP between two groups(P>0.05),and the level of MMP-8 in the experimental group was not significantly lower than that in the control group(P<0.05).After 3 months of periodontal initial therapy,the PLI was less than 20%,the complete BOP was 22.7%,and the PD>5 mm was 13.6%in the experimental group.Conclusion:Simple periodontal initial therapy can improve the periodontal clinical indexes of elderly patients with moderate to advanced periodontitis with type 2 diabetes,and reduce the level of MMP-8 in the whole saliva.Periodontal infection control is satisfactory.Compared with elderly patients with moderate to advanced periodontitis,the effect of inflammatory therapy is poor after periodontal initial therapy in elderly patients with mo-derate to advanced periodontitis and type 2 diabetes.
作者
苏哲君
王鹏
霍峰
李毅萍
陈雪
马莉
SU Zhe-jun;WANG Peng;HUO Feng;LI Yi-ping;CHEN Xue;MA Li(Department of Stomatology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China;Xiangya School of Stomatology,Zhongnan University,Changsha 410078,China)
出处
《口腔医学研究》
CAS
北大核心
2018年第11期1196-1199,共4页
Journal of Oral Science Research
基金
河北省科技计划项目(编号:17277760D)
承德市科学技术研究与发展计划项目(编号:20142052)
政府资助临床医学优秀人才培养和基础课题研究项目(2016)
关键词
2型糖尿病
慢性牙周炎
牙周基础治疗
基质金属蛋白酶-8
Type 2 diabetes mellitus
Chronic periodontitis
Periodontal initial therapy
Matrix metalloproteinase-8
