摘要
目的观察前列地尔治疗高龄糖尿病并慢性肾脏病的临床疗效。方法 84例高龄糖尿病并慢性肾脏病患者,随机分为实验组和对照组,每组42例。对照组给予常规治疗,实验组给予常规治疗联合前列地尔治疗。比较两组疗效,治疗前后血尿素氮(BUN)、尿蛋白排泄率(UAER)、血肌酐(Cr)水平及不良反应发生情况。结果实验组临床治疗总有效率为90.48%(38/42),显著高于对照组的71.43%(30/42),差异有统计学意义(P<0.05)。治疗前,两组患者的BUN、UAER和Cr水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者的BUN、UAER和Cr水平均较本组治疗前降低,且观察组降低程度优于对照组,差异均具有统计学意义(P<0.05)。实验组不良反应7.14%低于对照组26.19%,差异有统计学意义(P<0.05)。结论前列地尔能够显著提高高龄糖尿病并慢性肾脏病患者的临床治疗效果,迅速改善、控制BUN、UAER和Cr水平,不良反应少,高效安全,值得临床大力推广。
Objective To observe the clinical efficacy of alprostadil in the treatment of aged diabetes mellitus complicated with chronic kidney disease.Methods A total of 84 aged patients with diabetes mellitus and chronic kidney disease were randomly divided into experimental group and control group,with 42 cases in each group.The control group received conventional therapy,and the experimental group received conventional therapy and alprostadil for treatment.Comparison were made on efficacy,blood urea nitrogen(BUN),urinary albumin excretion rate(UAER),serum creatinine(Cr)levels before and after treatment and adverse reactions between the two groups.Results The experimental group had significantly higher total effective rate of clinical treatment as 90.48%(38/42)than 71.43%(30/42)in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in BUN,UAER and Cr level(P>0.05).After treatment,both groups had lower BUN,UAER and Cr level than those before treatment,and the observation group had better decline degree than the control group.Their difference was statistically significant(P<0.05).The experimental group had lower incidence of adverse reactions as 7.14%than 26.19%in the control group,and the difference was statistically significant(P<0.05).Conclusion Alprostadil can significantly improve the clinical treatment effect of elderly patients with diabetes and chronic kidney disease,rapidly improve and control the levels of BUN,UAER and Cr with fewer adverse reactions and high efficiency and safety.So it is worthy of clinical promotion.
作者
杨声军
YANG Sheng-jun(Department of Pharmacy,Shanwei People’s Hospital,Shanwei 516600,China)
出处
《中国现代药物应用》
2018年第22期95-96,共2页
Chinese Journal of Modern Drug Application
关键词
前列地尔
高龄
糖尿病
慢性肾脏病
Alprostadil
Aged
Diabetes mellitus
Chronic kidney disease
