摘要
背景:纳米级羟基磷灰石作为一种生物活性材料,以其优良的生物学性能受到广泛的关注,其对骨髓基质干细胞增殖、分化、矿化、细胞毒性等作用,是影响其成骨性能的重要因素,也是目前骨组织工程领域研究的一个热点问题。目的:探讨纳米羟基磷灰石对骨髓基质干细胞的作用,为组织工程化骨的深入研究提供指导。方法:由第一作者检索2006-01-01至2018-07-26PubMed、CNKI、维普、万方和谷歌学术数据库相关文献,英文检索词为"hydroxyapatite,nano-hydroxyapatite,biological matrix material,bone marrow stromal stem cells,osteogenic activity,biocompatibility,cytotoxicity,bone defect,bone tissue engineering,tissue engineered bone";中文检索词为"羟基磷灰石、纳米羟基磷灰石、生物基质材料、骨髓基质干细胞、成骨活性、生物相容性、细胞毒性、骨缺损、骨组织工程、组织工程化骨",共选取66篇文献进行综述。结果与结论:大量研究表明,纳米羟基磷灰石及其复合材料与骨髓基质干细胞具有良好的亲和性、黏附性和生物相容性,能诱导骨髓基质干细胞的增殖和分化,是一种较为理想的骨缺损修复材料,可广泛应用于骨缺损的修复和种植体的表面改性,能够促进新骨早期形成,并增强种植体与骨组织之间的结合强度;纳米羟基磷灰石复合材料还被用于研制生物型人工韧带、引导性骨组织再生膜材料和治疗股骨头坏死等。对纳米羟基磷灰石与骨髓基质干细胞相互作用的深入研究,必将推动组织工程化骨的研究进展和临床应用。
BACKGROUND:As a kind of bioactive material,nano-hydroxyapatite has received extensive attention for its excellent biological performance.Its effect on the proliferation,differentiation,mineralization and cytotoxicity of bone marrow stromal stem cells is an important factor affecting its osteogenesis performance,and it is also a current hot topic in the field of bone tissue engineering.OBJECTIVE:To explore and analyze the effect of nano-hydroxyapatite on bone marrow stromal stem cells and to provide guidance for further study of tissue engineered bone.METHODS:Relevant literature published from January 1,2006 to July 26,2018 was retrieved by the first author in PubMed,CNKI,VIP,WanFang and Google Scholar.The keywords were“hydroxyapatite,nano-hydroxyapatite,biological matrix material,bone marrow stromal stem cells,osteogenic activity,biocompatibility,cytotoxicity,bone defect,bone tissue engineering,tissue engineered bone”in English and Chinese,respectively.Sixty-six eligible articles were finally reviewed.RESULTS AND CONCLUSION:A large number of studies have shown that the nano-hydroxyapatite and its composite materials with bone marrow stromal stem cells have good affinity,adhesion and biocompatibility,and can induce the proliferation and differentiation of bone marrow stromal stem cells.Nano-hydroxyapatite is an ideal material for bone defect repair,which can be widely used in bone defect repair and surface modification of implants,thereby promoting early new bone formation and strengthening the binding between implants and bone tissues.Nano-hydroxyapatite composite materials are also used to develop biological artificial ligaments and guided bone tissue regeneration membrane materials as well as to treat femoral head necrosis.Further investigations on the interaction between nano-hydroxyapatite and bone marrow stromal stem cells will certainly promote the research progress and clinical application of tissue-engineered bone.
作者
李璐
舒静媛
郑丽霞
崔颖颖
牛月月
王倩
王青山
Li Lu;Shu Jingyuan;Zheng Lixia;Cui Yingying;Niu Yueyue;Wang Qian;Wang Qingshan(Department of Pediatric Stomatology,Affiliated Hospital of Binzhou Medical University,Binzhou 256603,Shandong Province,China;Department of Stomatology,Liaocheng Retired Soldier Hospital,Liaocheng 252000,Shandong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第1期132-138,共7页
Chinese Journal of Tissue Engineering Research
基金
山东省自然科学基金项目(ZR2018LH010)
项目负责人:王青山
山东省医药卫生科技发展计划(2013WS0308)
项目负责人:王青山~~
