摘要
采用脂多糖LPS诱导的弥散性血管内凝血DIC模型,探讨复方血栓通胶囊对肝肾等器官的损伤以及血栓沉积的影响。结果表明,复方血栓通胶囊能够显著抑制DIC模型大鼠天冬氨酸氨基转移酶、丙氨酸氨基转移酶、尿素氮、肌酐的升高,显著抑制肝肾组织血栓的形成、出血以及炎性细胞的浸润。本研究为复方血栓通胶囊的临床合理用药提供了依据。
The effects of Compound Xueshuantong Capsule(CXC)on the hepatic and renal function of rats with disseminated intravascular coagulation were assessed.Biochemical tests showed that CXC could significantly decrease the levels of the alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in liver,and the levels of the urea nitrogen(UN)and creatinine(CR)in kidney.Histological observations showed that CXC could significantly inhibit thrombosis,hemorrhage,and inflammation infiltration in both liver and kidney.The results indicated that CXC could significantly improve the liver and kidney function,providing useful references for its clinical medication.
作者
刘宏
生书晶
苏薇薇
LIU Hong;SHENG Shujing;SU Weiwei(School of Life Sciences,Sun Yat-sen University∥Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Marketed TCM, Guangzhou 510275,China)
出处
《中山大学学报（自然科学版）》
CAS
CSCD
北大核心
2018年第6期97-102,共6页
Acta Scientiarum Naturalium Universitatis Sunyatseni
基金
广东省名优中成药二次开发项目(2017-No.19)
关键词
复方血栓通胶囊
弥散性血管内凝血
肝肾功能
Compound Xueshuantong Capsule
disseminated intravascular coagulation
hepatic and renal function
