摘要
目的:分析梅毒住院患者的临床特征,为梅毒患者的随访监测及治疗提供可靠依据。方法:对2012年1月～2017年10月于我院皮肤性病科就诊的347例梅毒住院患者的临床资料进行回顾性分析。结果:347例梅毒患者男女比例为1∶1. 71,20～39岁年龄段感染率最高,其中隐性梅毒较多见,且已婚患者居多。血清高滴度组(TRUST≥1∶8)脑脊液阳性检出率(71. 43%)高于血清低滴度组(TRUST<1∶8)脑脊液阳性检出率(36. 0%),差异有统计学意义(χ~2=28. 705,P<0. 001)。脑脊液单、双阳组中有症状者所占比例均高于脑脊液双阴组,差异均有统计学意义(P<0. 05);脑脊液双阳组中有症状者和脑脊液单阳组间差异无统计学意义(P>0. 05)。结论:血清持续高滴度(TRUST≥1∶8)不阴转或复升的梅毒患者更容易发生神经受累,建议住院行脑脊液检查排除神经受累可能。脑脊液阳性患者神经受累症状明显,应该积极予以驱梅治疗促进有症状患者的神经功能恢复。
Objective:To analyze the clinical features of syphilis in hospitalized patients for evidence in planning follow-up monitoring and treatment of this entity.Methods:Retrospective analysis was performed on the clinical data of 347 hospitalized patients with syphilis treated in our department from January 2012 to October 2017.Results:In the 347 hospitalized patients with syphilis,the male to female ratio was 1∶1.71.Patients aged from 20 to 39 years were most predisposed to the infection,and latent syphilis was most common,particularly in married patients.Positive cerebral spinal fluid(CSF)was detected in 71.43%of the patients with higher TRUST(≥1∶8)and 36%of those with lower TRUST(<1∶8).The difference was significant(χ2=28.705,P<0.001).The proportion of symptomatic patients in the CSF single and double positive groups were higher than that in the CSF double negative group,with statistical differences(P>0.05),yet difference was insignificant between patients with double CSF positivity and those with single CSF positivity(P>0.05).Conclusion:Neurological involvement more likely occur in patients of syphilis with higher serum TRUST(≥1∶8)or without titer reversion or increased TRUST level,for which these patients are recommended to be admitted to the hospital to undergo CSF determination.Patients with typical neurological symptom by CSF determination should receive timely treatment to improve the neurology recovery.
作者
宋家俊
何彩凤
林丽
刘雯蓓
王军
SONG Jiajun;HE Caifeng;LIN Li;LIU Wenbei;WANG Jun(Department of Dermatology and STD,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)
出处
《皖南医学院学报》
CAS
2018年第6期573-575,共3页
Journal of Wannan Medical College
基金
皖南医学院重点科研项目培育基金(WK2018ZF08)
关键词
梅毒
血清学
脑脊液
syphilis
serum
cerebrospinal fluid
