摘要
细胞焦亡是一种新发现的细胞程序性死亡方式,通过诱发炎症反应和破坏细胞膜完整性导致细胞死亡,近年来发现其与阿尔兹海默病的发病有密切关系:炎症小体可能参与β淀粉样蛋白的形成,其下游产物白细胞介素-1β和白细胞介素-18可能参与介导神经炎症反应,同时细胞焦亡导致神经元丢失。另外中医药可以有效干预细胞焦亡。研究细胞焦亡与阿尔兹海默病的关系有助于进一步阐明阿尔兹海默病的分子机制,为发现新的治疗靶点提供依据。
Pyroptosis is a new type of programmed cell death.Pyroptosis tightly controls inflammatory response and destroys cell membranes,which finally induces cell death.From the current knowledge of the role of pyroptosis in Alzheimer disease,we can see that there are several connections between pyroptosis and Alzheimer disease.Frist of all,Inflammasome might play a major role in triggering Amyloid plaques-clumps of protein accumulation.Second,pyroptosis might activate caspase-1 for the subsequent maturation of pro-inflammatory cytokines,IL-1βand IL-18,which could be implicated in the execution of inflammatory response.Third,pyroptosis leads to neuronal cell death which is associated with pathogenetic mechanisms in Alzheimer disease.The goal of this article is to discuss the connection between Pyroptosis and Alzheimer disease so to find out the new therapeutic strategies targeting Alzheimer Disease.
作者
黑鑫鑫
刘涛
HEI Xing-xing;LIU Tao(School of Basic Medical Sciences,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2018年第12期1319-1324,共6页
Journal of Medical Postgraduates
基金
国家自然科学基金(81173313)
