摘要
目的观察丹蒌片治疗冠心病心绞痛痰瘀互结证的临床效果及其对血管内皮功能的影响。方法将70例冠心病心绞痛痰瘀互结证患者随机分为联合组和对照组,各35例。两组均给予常规西药对症治疗,联合组在此基础上加服丹蒌片,两组疗程均为4周。比较治疗前后两组患者中医症候评分、临床症状及血管内皮功能。结果治疗后,两组中医症候评分均较治疗前下降,且联合组低于对照组(均P <0. 05);两组心绞痛发作频率及持续时间、心肌缺血总负荷少于或低于治疗前,且联合组少于或低于对照组(均P <0. 05);两组内皮素-1(ET-1)、血管紧张素Ⅱ(AngⅡ)水平较治疗前降低,一氧化碳(NO)、降钙素基因相关肽(CGRP)水平较治疗前升高,且联合组的ET-1、AngⅡ水平低于对照组,NO、CGRP水平高于对照组(均P <0. 05)。结论丹篓片可有效缓解冠心病心绞痛痰瘀互结证患者的临床症状,并改善血管内皮功能。
Objective To observe the clinical efficacy of Danlou Tablets and its impact on the vascular endothelial function in coronary heart disease and angina pectoris with syndrome of intermingling of phlegm and static blood.Methods Seventy patients,who suffered from coronary heart disease and angina pectoris with syndrome of intermingling of phlegm and static blood,were randomly divided into combination group(n=35)and control group(n=35).Based on the symptomatic therapy with conventional western medicine performed in the two groups,the combination group was given Danlou Tablets additionally,and the treatment course was4weeks in both groups.The score of traditional Chinese medicine(TCM)syndromes,clinical symptoms and vascular endothelial function before and after treatment were compared between the two groups.Results After treatment,the score of TCM syndromes decreased in both groups compared with the score before treatment,and the score in the combination group was lower than that in the control group(all P<0.05);the frequency and duration of angina pectoris attack and the total load of myocardial ischemia were less or lower in both groups than those before treatment,and the indices in the combination group were less or lower compared with those in the control group(all P<0.05);the levels of endothelin-1(ET-1)and angiotensinogenⅡ(AngⅡ)decreased while the levels of nitric oxide(NO)and calcitonin gene-related peptide(CGRP)increased in both groups compared with the levels before treatment,and moreover,the levels of ET-1and AngⅡwere lower and the levels of NO and CGRP were higher in the combination group than those in the control group(all P<0.05).Conclusion Danlou Tablets can effectively alleviate the clinical symptoms and improve vascular endothelial function in treating the patients suffering from coronary heart disease and angina pectoris with syndrome of intermingling of phlegm and static blood.
作者
王玉华
佟士骅
丁毓
鲁成
庄少伟
WANG Yu-hua;TONG Shi-hua;DING Yu;LU Cheng;ZHUANG Shao-wei(Department of Cardiology,the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)
出处
《广西医学》
CAS
2018年第21期2524-2526,2530,共4页
Guangxi Medical Journal
基金
上海市科学技术委员会科研课题(9312012J1081)
关键词
冠心病
心绞痛
痰瘀互结证
丹蒌片
血管内皮功能
Coronary heart disease
Angina pectoris
Symptom of intermingling of phlegm and static blood
Danlou Tablets
Vascular endothelial function
