摘要
目的观察益气活血解毒制剂化纤胶囊对脓毒症凝血功能及抗凝血酶Ⅲ(AT-Ⅲ)、血小板活化因子(PAF)的影响。方法 Wister雄性大鼠40只随机分为空白组、假手术组、模型对照组、化纤胶囊干预组。造模后给药3 d后检测各组凝血指标、抗凝血酶Ⅲ(AT-Ⅲ)、血小板活化因子(PAF)。结果模型组的凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、PAF、纤维蛋白原(FIB)明显高于空白组、假手术组,AT-Ⅲ低于空白组、假手术组(P <0.05),化纤组的PT、APTT、TT、PAF、FIB明显低于模型组并且高于空白组、假手术组(P <0.05),化纤组的AT-Ⅲ明显高于模型组(P <0.05)。结论益气活血解毒方化纤胶囊可改善脓毒症凝血功能,为中医治疗脓毒症提供理论依据。
Objective:To investigate the effects of Huaxian Capsules on coagulation function,AT-Ⅲand PAF in sepsis.Methods:40Wister male rats were randomly divided into the blank group,sham operation group,the model control group and Huaxian Capsules intervention group.After3days of administration,the coagulation indexes,AT-Ⅲand PAF were detected.Results:PT,APTT,TT,PAF and FIB in the model group were significantly higher than those in the blank group and sham operation group;AT-Ⅲwas lower(P<0.05).PT,APTT,TT,PAF and FIB in Huaxian Capsules group were significantly lower than those in the model group and higher than those in the blank group and sham operation group(P<0.05),and AT-Ⅲwas significantly higher than that in the model group(P<0.05).Conclusion:Huaxian Capsules of Yiqi Huoxue Jiedu Decoction can improve the coagulation function of sepsis and provide theoretical basis for the treatment of sepsis with traditional Chinese medicine.
作者
王丛
梁群
Wang Cong;Liang Qun(Heilongjiang University of Chinese Medicine,Heilongjiang,Harbin 150040,China)
出处
《中国中医急症》
2018年第12期2086-2088,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金项目(81774276)
黑龙江省哈尔滨市应用技术研究与开发项目(优秀学科带头人)(2017RAXXJ037)
黑龙江中医药大学科研基金资助项目(2017XY03)
