摘要
目的探讨顺铂腹腔灌注对卵巢癌的疗效评价及对PI3K/Akt信号通路的影响。方法收集2014年3月～2016年9月间本院收治的晚期卵巢癌患者78例,经随机数字表法分为对照组及观察组,各39例。对照组患者接受常规静脉化疗,观察组患者接受顺铂腹腔灌注联合静脉化疗。对比两组患者近期疗效、血清卵巢癌肿瘤标志物含量、癌性腹水中PI3K/Akt信号通路相关分子表达量的差异。结果治疗3个疗程后,观察组患者的总有效率高于对照组(P <0.05);观察组患者血清中卵巢癌相关肿瘤标志物人附睾蛋白4(HE4)、细胞角蛋白19片段(CYDRA21-1)、组织特异性抗原(TPS)的含量低于对照组患者(P <0.05);观察组患者癌性腹水中PI3K/Akt信号通路相关分子PI3K、Akt蛋白的表达量低于对照组患者(P <0.05)。结论晚期卵巢癌患者接受顺铂腹腔灌注联合常规化疗,可更为有效的提升治疗效果,具体机制与其抑制PI3K/Akt信号通路功能直接相关。
Objective To explore the efficacy of cisplatin peritoneal perfusion in ovarian cancer and its effect on PI3K/Akt signaling pathway.Methods78patients with advanced ovarian cancer in our hospital from March2014to September2016were collected,and divided into the control group and the observation group according to random number table method,each group had39cases.The control group was received conventional intravenous chemotherapy,the observation group was received cisplatin peritoneal perfusion and intravenous chemotherapy.The short-term efficacy,serum ovarian cancer markers and related molecular expression of PI3K/Akt signaling pathway in malignant ascites were compared between the two groups.Results After3courses of treatment,the total effective rate of the observation group was higher than the control group(P<0.05).The serum levels of ovarian cancer-associated tumor markers,human epididymis protein4(HE4),cytokeratin19fragment(CYDRA21-1),and tissue specific antigen(TPS)were lower in the observation group than the control group(P<0.05).The expression levels of PI3K and Akt proteins related to PI3K/Akt signaling pathway in patients with malignant ascites in the observation group were lower than the control group(P<0.05).Conclusion Cisplatin peritoneal perfusion combined with conventional chemotherapy in the treatment of advanced ovarian cancer can more effectively improve the therapeutic effect,the specific mechanism is directly related to its inhibition of PI3K/Akt signaling pathway function.
出处
《中国医药科学》
2018年第21期18-21,33,共5页
China Medicine And Pharmacy
