摘要
目的研究前哨淋巴结活检及微转移检测对乳腺癌的临床诊疗价值。方法选取乳腺癌患者133例,对其首先进行前哨淋巴结定位活检术,然后行根治性腋窝淋巴结清扫术。结果 133例乳腺癌患者中,每例检出前哨淋巴结1～5枚,平均3枚,共399枚;检出非前哨淋巴结5～20枚,平均(12. 5±2. 4)枚,共1596枚。单一层面切片的HE染色,前哨淋巴结发现45枚(8例)(17. 7%),非前哨淋巴结41枚(14例)(34. 1%)发现转移。对399枚前哨淋巴结行多层切片HE染色及免疫组化染色检测,发现单层切片常规HE染色前哨淋巴结均有微小转移,余下HE染色阴性的前哨淋巴结有微小转移灶,直径均小于2 mm,累计有96枚前哨淋巴结内有转移灶;对早期乳腺癌前哨淋巴结分别进行多层切片HE染色及免疫组化染色法与单一层面切片HE染色法相比,检出率提高,差异有统计学意义(P <0. 05)。结论前哨淋巴结活检及微转移的检测结果可以用来指导是否对乳腺癌患者进行常规腋淋巴结清扫,对其进行连续切片及免疫组化染色检测比普通HE染色检出率明显提高。
Objective To investigate the clinical value of sentinel lymph node biopsy and micrometastasis detection in breast cancer patients.Methods From May 2015 to June 2017,a total of 133 patients with breast cancer were diagnosed and treated in our hospital,First,sentinel lymph node biopsy was performed and radical axillary dissection was performed.Results Of the 133 patients with breast cancer who underwent this study,1~5 were sent to the sentinel lymph nodes,with an average of 399 patients and 5~20 non-sentinel lymph nodes,averaging 12.5±2.4,a total of 1596(n=8)(17.7%)and 41 sentinel lymph nodes(14 cases)(34.1%)found metastases.A total of 399 sentinel lymph nodes were examined by HE staining and immunohistochemical staining.It was found that the sentinel lymph nodes of the single HE staining were slightly metastatic.The left HE of the sentinel lymph nodes had a small metastatic lesion with a diameter of less than 2mm.There were 96 sentinel lymph nodes in the sentinel lymph nodes.The sentinel lymph nodes of the early breast cancer were divided into HE staining,immunohistochemical staining and HE staining,and the difference was statistically significant(P<0.05).Conclusion Sentinel lymph node biopsy and detection of micrometastasis of breast cancer can be used to guide the patients for routine axillary lymph node dissection and staining staining rate significantly higher than that of ordinary HE for serial sectioning and immunohistochemistry.
作者
苗茁
张静波
张红战
赵小军
MIAO Zhuo;ZHANG Jingbo;ZHANG Hongzhan(Jiyuan City Cancer Hospital,Jiyuan,459000)
出处
《实用癌症杂志》
2018年第12期1950-1952,共3页
The Practical Journal of Cancer
关键词
前哨淋巴结活检
微转移检测
乳腺癌
Sentinel lymph node biopsy
Micrometastasis detection
Breast carcinoma
