摘要
目的探讨左西孟旦治疗老年难治性心力衰竭合并肾功能不全的临床效果及安全性。方法选取2015年1月至2017年9月本院收治的112例难治性心力衰竭合并肾功能不全的老年患者为研究对象,采用随机数表法将其分为研究组(左西孟旦治疗)和对照组(常规治疗),每组各56例。比较两组患者治疗前后的心肾功能指标、临床疗效及不良反应发生率。结果治疗后,两组患者左心室射血分数、每搏输出量、心脏指数及估算肾小球滤过率均显著高于本组治疗前(P_均<0.05),且研究组患者上述指标水平均显著高于对照组(P_均<0.05),血清肌酐水平显著低于对照组(P <0.05);研究组患者的临床疗效显著优于对照组(P <0.05),总有效率显著高于对照组(P <0.05)。两组患者不良反应发生率无显著差异(P> 0.05)。结论左西孟旦能够有效改善老年难治性心力衰竭合并肾功能不全患者的心肾功能,且安全性好。
Objective To investigate the clinical efficacy and safety of Levosimendan in the treatment of elderly patients with refractory heart failure and renal insufficiency.Method112elderly patients with refractory heart failure and renal insufficiency in our hospital were selected as the study subjects from January2015to September2017,they were randomly divided into study group(Levosimendan treatment,n=56)and control group(conventional treatment,n=56),cardiac and renal function indexes before and after treatment,clinical efficacy and incidence of adverse reactions after treatment of the two groups were compared.Result After treatment,the left ventricular ejection fraction,stroke output,cardiac indexes and estimated glomerular filtration rate of the two groups were significantly higher than those before treatment(Pall<0.05),and above indexes levels in study group were significantly higher than those in control group(Pall<0.05),and the serum creatinine level was significantly lower than that of control group(P<0.05).The clinical efficacy of study group was better than that of control group(P<0.05),and the total effective rate was significantly higher than that of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Levosimendan can significantly improve the heart and kidney function of elderly patients with refractory heart failure and renal insufficiency,and the safety is good.
作者
韩友建
张湘瑜
HAN You-jian;ZHANG Xiang-yu(Department of Geriatrics,the Second Xiangya Hospital of Central South University,Changsha 410016,China)
出处
《中国医学前沿杂志（电子版）》
2018年第12期60-63,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
