摘要
脑卒中是严重危害人类健康的疾病之一,由于缺乏对缺血后引起神经元细胞死亡的细胞和分子机制的深入了解,目前缺乏有效治疗手段。本文从细胞凋亡、兴奋性毒性、氧化和硝化应激、炎症反应、先天和适应性免疫细胞、肠道菌群以及颅内动脉粥样硬化等方面,对缺血性脑卒中的病理生理基础进行综述,并揭示其相互交织的信号通路机制,寻找可以有效治疗缺血性脑卒中的靶点,为开发缺血性脑卒中的治疗方案奠定基础。
Stroke is one of the diseases that seriously endanger human health without effective treatment at present,due to the lack of in-depth understanding of the cellular and molecular mechanisms underlying neuronal cell death after ischemia.In the present article,in order to lay the foundations for the development of therapeutic regimens for ischemic stroke,we review the underlying pathophysiology of ischemic stroke including apoptosis,excitotoxicity,oxidative and nitrative stress,inflammation,innate and adaptive immune cells,the gutmicrobiota and intracranial atherosclerosis,and reveal the intertwinedpathways that are promising therapeutic targets.
作者
樊文香
FAN Wenxiang(Department of Pharmacy,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2018年第6期751-759,共9页
Journal of China Pharmaceutical University
关键词
缺血性脑卒中
兴奋性毒性
氧化应激
炎症
凋亡
ischemic stroke
excitotoxicity
oxidative stress
inflammation
apoptosis
