摘要
目的分析超选择性动脉溶栓与静脉溶栓治疗急性脑梗死(ACI)的临床效果。方法选取2015年9月～2017年4月太原市中心医院收治的75例ACI患者作为研究对象,按照病床单双号将其分为观察组(38例)和对照组(37例)。观察组患者采用阿替普酶超选择性动脉溶栓治疗,对照组患者采用阿替普酶静脉溶栓治疗。比较两组患者的治疗效果、治疗前后脑卒中量表(NIHSS)评分、血管再通率及脑出血情况。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的NIHSS评分比较,差异无统计学意义(P>0.05);两组患者治疗后7 d及1个月的NIHSS评分均低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后7 d及1个月的NIHSS评分均低于对照组,差异有统计学意义(P<0.05)。观察组患者的血管总再通率高于对照组,脑出血率低于对照组,差异有统计学意义(P<0.05)。结论 ACI患者以超选择性动脉溶栓进行治疗,治疗期间脑出血率低、疗效高、血管再通率高、神经功能改善好。
Objective To analyze the clinical effect analysis of superselective intra-arterial thrombolysis and intravenous thrombolysis in the treatment of acute cerebral infarction(ACI).Methods A total of 75 ACI patients treated in Taiyuan Central Hospital from September 2015 to April 2017 were selected as subjects.They were divided into the observation group(n=38)and the control group(n=37)according to the odd/even number of hospital bed.Patients in the observation group were treated with Alteplase for superselective intra-arterial thrombolysis,and patients in the control group were treated with Alteplase for intravenous thrombolysis.The treatment effect,stroke scale(NIHSS)scores before and after treatment,recanalization rate,and cerebral hemorrhage were compared between the two groups.Results The total effective rate of the treatment of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the NIHSS scores between the two groups before treatment(P>0.05).The NIHSS scores 7 days and 1 month after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The NIHSS scores 7 days and 1 month after treatment in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total recanalization rate of the patients in the observation group was higher than that in the control group,the cerebral hemorrhage rate was lower than that in the control group,and the differences were statistically significant(P<0.05).Conclusion The superselective intra-arterial thrombolysis in the treatment of ACI can reduce the incidence rate of cerebral hemorrhage,increase the efficacy and recanalization rate,and improve the neurological function.
作者
温超
曹江红
WEN Chao;CAO Jiang-hong(Department of Neurology,Taiyuan Central Hospital,Shanxi Province,Taiyuan030009,China;Department of Intensive Care Unit,Shanxi Provincial People′s Hospital,Taiyuan030000,China)
出处
《中国当代医药》
2018年第34期77-80,共4页
China Modern Medicine
关键词
急性
动脉溶栓
脑梗死
疗效
静脉溶栓
Acute
Intra-arterial thrombolysis
Cerebral infarction
Efficacy
Intravenous thrombolysis
