摘要
目的观察头穴电针结合多巴丝肼片治疗帕金森病(PD)的临床疗效。方法选取2016年3月至2017年10月黑龙江中医药大学附属第二医院收治的90例PD患者作为研究对象,按随机数字法分为A组、B组、C组,每组30例。其中,A组采用头穴电针结合口服多巴丝肼片联合普通针刺治疗,B组采用头穴电针联合普通针刺治疗,C组采用口服多巴丝肼片联合普通针刺治疗,针刺治疗为每天上午9:00～11:00进行,连续针刺6 d,休息1 d,共治疗4周。观察3组患者的临床疗效,H-Y分期量表、统一帕金森病评定量表(UPDRS)、PD睡眠量表(PDSS)评分,以及脑内的乙酰胆碱(Ach)和多巴胺(DA)水平。结果治疗后,与B组和C组相比,A组的治疗效果显著,差异有统计学意义(P <0. 05)。治疗后,3组患者的H-Y分期评分差异有统计学意义(P <0. 05);且3组间两两比较,差异有统计学意义(P <0. 05)。治疗后,3组患者的UPDRS评分较治疗前降低、PDSS评分较治疗前升高(P <0. 01);且3组间两两比较,差异有统计学意义(P <0. 05); 3组患者的Ach水平差异无统计学意义(P> 0. 05),DA水平差异有统计学意义(P <0. 01)。结论头穴电针结合多巴丝肼片治疗帕金森病的疗效显著。
Objective To observe the clinical curative effect of electroacupuncture of head acupoint combined with levodopa and benserazide hydrochloride tablets in the treatment of Parkinson′s disease(PD).Methods Ninety PD patients admitted to the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from Mar.2016to Oct.2017were included in the study,according to the random number method,they were divided into group A,group B and group C,30cases in each group.Group A was treated by electroacupuncture of head acupoint combined with levodopa and benserazide hydrochloride tablets combined with ordinary acupuncture,group B with electroacupuncture of head acupoint combined with ordinary acupuncture,group C with levodopa and benserazide hydrochloride tablets combined with ordinary acupuncture.The acupuncture treatment was carried out at9-11a.m.,every day for6days,rest for1day,for4weeks in total.The clinical efficacy,Hoehn-Yahr(H-Y)staging scale,unified PD rating scale(UPDRS),PD sleep scale(PDSS)score,and the levels of acetylcholine(Ach)and dopamine(DA)in the brain of the three groups were observed.Results After treatment,compared with group B and group C,the treatment effect of group A was significantly better(P<0.05).After treatment,there was significant difference in H-Y staging score among the three groups(P<0.05),and there was significant difference between either two of the three groups(P<0.05).After treatment,the UPDRS scores of the three groups were lower than those before treatment,and the PDSS scores were higher than those before treatment(P<0.01),and the difference was statistically significant between either two of the three groups(P<0.05);the level of Ach in the three groups was not statistically significantly different(P>0.05),and the level of DA was statistically significantly different(P<0.01).Conclusion Electroacupuncture of head acupoint combined with levodopa and benserazide hydrochloride tablets has significant curative effect on PD.
作者
王琳晶
陈静
安微
王春英
王璐
林春盛
卢芳
尚莉莉
WANG Linjing;CHEN Jing;AN Wei;WANG Chunying;WANG Lu;LIN Chunsheng;LU Fang;SHANG Lili(Department of Acupuncture and Moxibustion,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China;Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Continuing Education Institute,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《医学综述》
2018年第23期4746-4751,共6页
Medical Recapitulate
基金
国家自然科学基金(81270056)
黑龙江省卫生计生委科研课题(2017-572)
黑龙江省中医药管理局中医药科研项目(ZHY18-067)
黑龙江中医药大学附属第二医院科研项目(YM-201703)
关键词
帕金森病
头穴
电针
多巴丝肼片
Parkinson′s disease
Head acupoint
Electroacupuncture
Levodopa and benserazide hydrochloride tablets
