摘要
目的观察奥曲肽联合复方小承气汤对术后麻痹性肠梗阻疗效及炎性因子水平的影响。方法选取我院腹部术后麻痹性肠梗阻患者176例,随机分为对照组和观察组,每组88例。对照组患者予禁食、胃肠减压、纠正水电解质和酸碱平衡紊乱、全胃肠外营养以及使用抗生素和奥曲肽等治疗。观察组除上述治疗外加用复方小承气汤经胃管注入,每天1次,连续使用。结果 7 d观察组患者腹胀腹痛缓解时间、恶心呕吐缓解时间、肛门首次排气时间、首次进食时间和住院时间均显著短于对照组(P<0.01),胃肠减压量显著少于对照组(P<0.01),腹围减小程度显著高于对照组(P<0.01)。观察组患者治疗总有效率显著高于对照组患者(P<0.01)。治疗后观察组患者血浆肿瘤坏死因子-α、白介素-6和C反应蛋白水平均显著低于对照组患者(P<0.01)。结论奥曲肽联合复方小承气汤治疗术后麻痹性肠梗阻可进一步缩短患者症状的缓解时间,提高治疗有效率,降低血浆炎性因子水平,适合在临床上推广。
Objective To explore the therapeutic effect of octreotide combined xiaochengqi tang on postoperative ileus patients and their inflammatory factors level.Methods 176 postoperative ileus patients were assigned to the control group and observation group(n=88).Patients in the control group received fasting,gastrointestinal decompression,water-electrolyte and acid-base disturbance correction,total parenteral nutrition,antibiotics treatment and octreotide treatment.Patients in the observation group received above treatments and xiaochengqi tang injection through stomach tube daily for 7 d.Results Abdominal distension and pain,nausea and vomiting remission time,passage gas anus time,first feeding time and hospitalization time in the observation group were significantly shorter than that in the control group(P<0.01).Gastrointestinal decompression volume was lower and the abdominal perimeter reduction were higher in the observation group compared with that in the control group(P<0.01).Therapeutically effective rate were higher in the observation group than that in the control group significantly(P<0.01).Serous tumor necrosis factor-α,interleukin-6 and C-reactive protein were significantly lower than that in the control group after treatment(P<0.01).Conclusion Octreotide combined xiaochengqi tang could shorten symptom relief time,enhance therapeutically effective rate,reduce serous inflammatory factor level in postoperative ileus patients,which should be popularized clinically.
作者
刘华春
杨根
LIU Hua-chun;YANG Gen(Intensive Care Unit,the People’s Hospital of Lianjiang City,Zhanjiang 524400,China)
出处
《广东医科大学学报》
2018年第5期530-533,共4页
Journal of Guangdong Medical University
基金
广东省中医药局科研项目(No.20182180)
关键词
奥曲肽
复方小承气汤
术后麻痹性肠梗阻
炎性因子
octreotide
combined xiaochengqi tang
postoperative ileus
inflammatory factors
