摘要
目的探索以伊立替康为主导的化疗方案对进展期胃癌新辅助化疗的可行性及安全性。方法选择我院2008年6月～2017年10月收治的进展期胃癌患者73例,术前给予伊立替康、亚叶酸钙、5-氟尿嘧啶联合化疗两个周期后手术。记录患者化疗的有效率及毒副反应。结果患者的毒副反应主要表现在血液系统及胃肠管系统,泌尿系统、心血管系统及神经系统未见明显不良反应。有1例因较为严重的骨髓抑制而提前结束化疗,其余均顺利完成。参照实体瘤疗效评估标准(RECIST),化疗有效率为78.13%,无效率为21.88%。结论胃癌患者对伊立替康联合亚叶酸钙、5-氟尿嘧啶的新辅助化疗方案有较好的耐受性,且该方法有较好的疗效。
Objective To explore the feasibility and safety of irinotecan-based chemotherapy regimen for neoadjuvant chemotherapy for advanced gastric carcinoma.Methods73patients with advanced gastric carcinoma admitted to our hospital from June2008to October2017were enrolled.Two cycles after irinotecan,leucovorin and5-fluorouracil were given before surgery.The chemotherapy efficiency and toxicity of the patients were observed.side effects.Results The patient's toxic and side effects were mainly manifested in the blood system and gastrointestinal system.No obvious adverse reactions were found in the urinary system,cardiovascular system and nervous system.1patient had early termination of chemotherapy due to more severe myelosuppression,and the rest were successfully completed.According to the solid tumor evaluation criteria(RECIST),the effective rate of chemotherapy was78.13%,and the ineffective rate was21.88%.Conclusion Gastric carcinoma patients have better tolerance to irinotecan combined with calcium leucovorin and5-fluorouracil,and this method has a good effect.
作者
王绥能
梁贤文
孙光
侯开庆
彭勃
WANG Sui-neng;LIANG Xian-wen;SUN Guang;HOU Kai-qing;PENG Bo(Department of Gastroenterology,Xiangya Haikou Hospital,Central South University,Haikou570208,Hainan,China)
出处
《医学信息》
2018年第24期164-166,共3页
Journal of Medical Information
关键词
进展期胃癌
新辅助化疗
伊立替康
亚叶酸钙
5-氟尿嘧啶
Advanced gastric carcinoma
Neoadjuvant chemotherapy
Irinotecan
Leucovorin
5-fluorouracil
