摘要
长链非编码RNA (lncRNA)是指一类长度超过200个核苷酸,具有较低的编码潜力的RNA。自噬是真核细胞特有的生命现象,在细胞的生长发育和老化过程中清除多余或损伤细胞器,对维持细胞内环境稳态具有重要作用。lncRNA作为细胞代谢的关键调节器,通过调节自噬参与相关疾病治疗。本文就lncRNA在治疗肿瘤、心脑血管疾病、神经退行性疾病及细菌的感染中的作用进行总结,并分析其中lncRNA调节自噬的分子机制,同时对其他领域的应用前景进行展望,以期对相关疾病的治疗提供新思路。
Long non-coding RNA(lncRNA)refer to transcripts longer than 200 nucleotides that have a low coding potential.Autophagy,a unique life phenomenon of eukaryotic cells,removes excess or damaged organelles during cell growth and development and plays a key role in maintaining homeostasis.As a key regulator of cellular metabolism,lncRNA are involved in disease treatment by regulating autophagy.This article summarizes the role of lncRNA in the treatment of cancer,cardiovascular and cerebrovascular diseases,neurodegenerative diseases,and bacterial infections and analyzes the molecular mechanisms of lncRNA in regulating autophagy,along with prospects of its applications in other areas.
作者
贡歌
殷建
杨翔
张兴虎
张瑗
万文辉
GONG Ge;YIN Jian;YANG Xiang;ZHANG Xinghu;ZHANG Yuan;WAN Wenhui(Department of Geriatrics,Nanjing General Hospital of PLA,Nanjing 210002,China;Department of Orthopaedics,the Affiliated Jiangning Hospital,Nanjing Medical University,Nanjing 211100,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2018年第6期827-831,共5页
Acta Academiae Medicinae Sinicae
基金
全军保健专项基金(13BJZ11
17BJZ17)
中国人民解放军南京总医院院管课题(2017065)~~
