摘要
目的:探讨胃蛋白酶原(PG)、胃泌素-17(G-17)水平在慢性萎缩性胃炎(CAG)患者中的表达及患者血清PGⅠ、G-17水平和PGⅠ/PGⅡ值与幽门螺杆菌(HP)感染的相关性。方法:选择经胃镜检查、组织病理学活检确诊的非萎缩性胃炎患者34例和CAG患者86例分别作为非萎缩组和观察组,并从同期健康体检者中招募43例作为对照组。测定三组受试者血清PGⅠ、PGⅡ和G-17水平,计算PGⅠ/PGⅡ值;同时测定观察组患者Hp感染情况。分析三组受试者血清PGⅠ和G-17水平及PGⅠ/PGⅡ值,胃窦、胃体、全胃不同胃黏膜萎缩病变程度与各指标相关性,各血清指标与HP感染相关性。结果:三组受试者血清PGⅠ、G-17水平及PGⅠ/PGⅡ值间比较差异存在统计学意义(P<0.05)。组间两两比较,与对照组比,非萎缩组及观察组患者血清PGⅠ水平及PGⅠ/PGⅡ值均明显下降,而G-17水平明显升高(P<0.05);与非萎缩组比,观察组PGⅠ水平及PGⅠ/PGⅡ值亦明显下降,G-17水平明显升高(P<0.05)。随萎缩病变严重程度加重,胃窦、胃体及全胃胃黏膜发生萎缩的CAG患者血清PGⅠ水平及PGⅠ/PGⅡ值呈现明显下降趋势(P<0.05);胃窦病变患者G-17水平随病情加重呈明显下降趋势(P<0.05);而胃体及全胃病变患者G-17水平则随病情加重呈明显上升趋势(P<0.05)。与HP(-)比,HP(+)者血清PGⅠ水平及PGⅠ/PGⅡ值均明显降低,G17水平明显升高(P<0.05)。结论:PG及G-17水平均可用于CAG筛查及患者胃黏膜萎缩病变程度的预测指标,尤其是HP+病例,PG及G-17优先检测对CAG早期筛查及病情判断具有重要意义。
Objective:To investigate the expression of pepsinogen(PG)and gastrin-17(G-17)in patients with chronic atrophic gastritis(CAG)and serum PGI,G-17and PGI/PGII values and Helicobacter pylori(Correlation of Helicobacter pylori,HP)infection.Methods:From January 2016to December 2017,34 patients with non-atrophic gastritis and86patients with CAG diagnosed by gastroscopy and histopathological biopsy from the First Hospital of Xi'an were selected as non-atrophy group and observation group,respectively.And43patients who were recruited from the same period of healthy physical examination set as the control group.The levels of serum PGI,PGII and G-17in the three groups were determined,and the PGI/PGII values were calculated.The HP infection in the observation group was also measured.The levels of serum PGI and G-17and the walues of PGI/PGII were analyzed in three groups.The correlation between the gastric mucosal atrophy degree and each index in gastric antrum,corpus,and whole stomach was analyzed,the correlation between serum markers and HP infection in CAG patients was analyzed.Results:There were statistically significant differences in serum PGI,G-17levels and PGI/PGII values between the three groups(P<0.05).The comparison between the two groups showed that compared with the control group,the serum PGI level and PGI/PGII value of the non-atrophy group and the observation group were significantly decreased,while the G-17level was significantly increased(P<0.05);Compared with the non-atrophy group,the PGI level and PGI/PGII value of the observation group also decreased significantly,and the G-17level was significantly increased(P<0.05).With the aggravation of atrophic lesions,serum PGI levels and PGI/PGII values of gastric atrophy in gastric antrum,corpus corpus and total gastric mucosa showed a significant decrease(P<0.05).The level of G-17in patients with gastric antrum was significantly decreased with the severity of the disease(P<0.05).The level of G-17in patients with gastric and total gastric lesions increased significantly with the severity of the disease(P<0.05).Compared with HP(-),the serum PGI level and PGI/PGII value of HP(+)were significantly decreased,and the G17level was significantly increased(P<0.05).Conclusion:Both PG and G-17levels can be used for CAG screening and predicting the extent of gastric mucosal atrophy in patients,especially in HP(+)cases.PG and G-17priority detection are important for early screening and disease judgment of CAG.
作者
高洁
GAO Jie(Clinical Laboratory of Xi 'an No. 1 Hospital,Xi’an 710000)
出处
《陕西医学杂志》
CAS
2019年第1期131-134,共4页
Shaanxi Medical Journal
基金
陕西省科技厅科研资助基金[2007K09-03-(4)]
