摘要
目的评价砂仁加速胃术后胃肠功能恢复的临床价值,在临床水平验证砂仁促进胃肠运动的机制,形成有中医药参与的胃术后加速康复外科的参考方案。方法选取胃术后患者40例,随机分为肠内营养(EN)组及砂仁组。EN组在一般支持对症治疗的基础上经鼻饲管滴入肠内营养制剂;砂仁组在EN组治疗基础上经鼻饲管滴入砂仁水提液。观察2组术后第1天和第5天血常规、肝功能及外周血胃动素(MLT)、P物质(SP)变化情况,记录2组肠鸣音恢复时间、首次排气时间、首次排便时间。结果 2组术后第1天、第5天血白细胞、白蛋白、ALT水平比较差异均无统计学意义(P均> 0. 05),砂仁组患者术后第1天、第5天MTL、SP水平均明显高于EN组(P均<0. 05);砂仁组患者术后肠鸣音恢复时间、排气排便时间均明显早于EN组(P均<0. 05)。结论砂仁能使胃术后患者较快地恢复胃肠功能,与促进体内MLT、SP的分泌释放有关,为中医药参与胃术后加速康复外科提供了参考方案。
Objective It is to evaluate the clinical value of Amomum villosum in accelerating the recovery of gastrointestinal function after gastric surgery,and to verify the mechanism of this drug's promotion of gastrointestinal motility at the clinical level,and to form a reference program for accelerated postoperative rehabilitation surgery with Chinese medicine.Methods Forty patients suffered from postoperative gastric surgery were randomly divided into enteral nutrition group and Amomum villosum group.The enteral nutrition group was instilled enteral nutrition preparation through nasogastric tube on the basis of general support for symptomatic treatment;the Amomum villosum group was dripped with the aqueous extract of Amomum villosum through the nasogastric tube on the basis of enteral nutrition group.The changes of blood routine,liver function and peripheral blood motilin(MLT)and substance P(SP)on the1st and5th day after operation were observed in the two groups.The recovery time of bowel sounds and first defecation time of the 2 groups was recorded.Results There was no significant difference in the levels of albumin and ALT between the two groups on the first and fifth day after operation(P>0.05).The levels of motilin and substance P in the Amomum villosum group were higher than those in the enteral nutrition group on the1st and5th day after operation(P<0.05).The recovery time of the bowel sounds and the first time of evacuation and defecation were significantly earlier in the Amomum villosum group than those in the enteral nutrition group(P<0.05).Conclusion Amomum villosum can restore gastrointestinal function quickly after gastric surgery,and its mechanism is related to promoting the release of motilin and substance P in the body.It provides a reference program for Chinese medicine to participate in accelerated postoperative surgery.
作者
曹羽
龚航军
韩刚
王以东
张云
CAO Yu;GONG Hangjun;HAN Gang;WANG Yidong;ZHANG Yun(Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)
出处
《现代中西医结合杂志》
CAS
2019年第1期19-22,62,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
上海市进一步加快中医药事业发展三年行动计划资助项目(ZY3-CCCX-2-1003)
关键词
砂仁
胃动素
P物质
快速康复外科
Amomum villosum
motilin
substance P
rapid rehabilitation surgery
