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308nm准分子光联合卡泊三醇倍他米松软膏治疗斑块状银屑病疗效分析 被引量:6

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摘要 目的:观察308nm准分子光联合卡泊三醇倍他米松软膏治疗斑块状银屑病的效果。方法:选取寻常型银屑病患者共360例,随机分为药物组、光疗组、联合组,每组各120例。药物组单用卡泊三醇倍他米松软膏涂于患处;光疗组采用希兰UV308nm准分子光疗仪照射;联合组皮损处给予308nm准分子光照射,同时外涂卡泊三醇倍他米松软膏。比较3组患者治疗天数、严重度指数(PAS1)、总有效率、不良反应及复发情况。结果:联合组治疗天数[(19.15±5.12)d]小于药物组[(28.13±4.98)d]和光疗组[(27.38±3.98)d](P<0.05),药物组和光疗组治疗天数比较无统计学差异(P>0.05);3组治疗前PASI评分比较无统计学差异(P>0.05),治疗后PASI评分比较,联合组(5.73±7.90)均低于药物组(8.79±7.90)和光疗组(8.73±8.56)(P<0.05),药物组与光疗组比较无统计学差异(P>0.05);3组改善率比较,联合组(80.83%)均高于药物组(67.42%)和光疗组(68.73%)(P<0.05),药物组与光疗组比较无统计学差异(P>0.05)。结论:308nm准分子光联合卡泊三醇倍他米松软膏治疗斑块状银屑病疗效好、疗程短、不良反应少。
作者 秦凌花 肖艳
出处 《长治医学院学报》 2018年第6期452-454,共3页 Journal of Changzhi Medical College
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  • 1胡亚莹,曹爱华,赵志明.澳能、炔维治疗斑块状银屑病疗效观察[J].岭南皮肤性病科杂志,2004,11(4):360-360. 被引量:1
  • 2罗小平.钙泊三醇和氟替卡松联合治疗头皮银屑病临床研究[J].临床研究,2010,17(22):35-36.
  • 3Manggau M, Kim DS, Ruwisch L, et al. 1,25-Dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1- phosphate [J].J Invest Demlatol, 2001, 117: 1241-1249.
  • 4Mattner F Smiroldo S, Galbiati F, et al. Inhibition of Thl deveh opment and treatment of chronic relapsing experimental allergic encephalomyelitis by a non-hypercacemic analogue of 1,25-di- hydroxy vitaminD3 [J]. Eur J lmmunol, 2000, 30: 498-508.
  • 5Piemonti L, Monti P, Sironi M, et al. Vitamin D3 afects di- fferentiation maturation,and function of human monoeyte-derived dendritic cells[J]. J Immunol, 2000, 164: 4443-4451.
  • 6Barrat FJ, Cua DJ, Boonstra A, et al. In vitro generation of interleukin-10-producing regulatory CD4^*T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 Thl and Th2-induceing cytokine[J]. J Exp Med, 2002, 195: 603- 616.
  • 7卫仲升等编写,赵 辨.临床皮肤病学[M]江苏科学技术出版社,1989.
  • 8Guenther L,Van de Kerkhof PC,Snellman E,et al.Efficacy and safety of a new combination of calcipotriol and betamethsone dipropionate (one or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgarisia randomized,double-blind,vehicle-controlled clinical trial. Bri J Dermatol . 2002
  • 9Seston EM,Ashcroft DM,Griffiths CE.Balancing the benefits and risks of drug treatment: a stated-preference, discrete choice experiment with patients with psoriasis. Archives of Dermatology . 2007
  • 10Niwa Y, Hasegawa T, Ko S, et al. Fcacy f 308nm cirne light for Japanese parleys with psoriasis[J]. J Dermatol,2009 ,6(11) :579 -582.

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