摘要
目的研究老年心衰患者血清基质金属蛋白酶3(matrix metalloproteinase-3, MMP3)水平与血浆B型脑钠肽(B-type natriuretic peptide, BNP)浓度之间的相关性,为心衰病理进程寻找新的标志物。方法化学发光法测定临床疑似心衰患者的血浆BNP;收集同期生化样本残余血清,免疫比浊法测定血清MMP3水平。结果 189例患者的BNP水平中位数为186 pg/mL(四分位间距为58.5,769);不同性别患者之间年龄及MMP3水平差异有统计学意义(P<0.05)。男性血清MMP3水平中位数为90.8 ng/mL(四分位间距为62.5,156.7),女性血清MMP3水平中位数为51.4 ng/mL(四分位间距为30.95,80.95)。女性患者血清Ln (MMP3)与Ln (BNP)之间的Pearson相关系数为0.378(P=0.002),排除年龄后的相关系数为0.349(P=0.004);男性患者血清Ln (MMP3)与Ln (BNP)之间的Pearson相关系数为0.605(P=0.000),排除年龄后的相关系数为0.625(P=0.000)。男性患者MMP3与BNP的相关性高于女性(P=0.00)。结论血清MMP3与BNP存在正相关,可考虑作为心衰的辅助诊断标志物。
Objective To explore the correlation between the level of matrix metalloproteinase-3(MMP3)and plasma density of B-type natriuretic peptide(BNP)in the elderlywith heart failure(HF)so as to find out the new markers for pathologic process ofHF.Methods Chemiluminescence methodwas applied in detecting the plasma density of BNP of the clinical suspected HF cases while immune turbidimetry was applied to detect the level of MMP3 in the residual serums collected from the biochemical analyzed samples at the same day.Results The median level of plasma BNP of 189 enrolled caseswas 186 pg/mL(interquartile58.5,769);there existed statistical differences in age and inMMP3levels betweenmales and females(P<0.05),the median level of serum MMP-3 was 90.8ng/mL(interquartile 62.5,156.7)in males while that was 51.4ng/mL(interquartile 30.95,80.95)in females;the Pearson correlation coefficient of Ln(MMP3)and Ln(BNP)was0.378(P=0.002)and was 0.349 after being adjustedwith age(P=0.004)in femaleswhile thatwas0.605(P=0.000)and was 0.625 after being adjustedwith age(P=0.000)in males;the coefficients of MMP3and BNP in males were higher than those in females(P=0.00).Conclusions The level of MMP3is positively correlated with the level of BNP and it may be taken as an auxiliary marker in HF diagnosis.
作者
潘逸茹
喻红之
薛惠君
陆元善
Pan Yiru;Yu Hongzhi;Xue Huijun;Lu Yuanshan(Department of Laboratory, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040;Department of Transfusion,Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, 200080, P. R. China)
出处
《老年医学与保健》
CAS
2018年第6期599-601,共3页
Geriatrics & Health Care
关键词
心力衰竭
基质金属蛋白酶3
B型脑钠肽
heart failure(HF)
matrix metalloproteinase-3(MMP3)
B-type natriuretic peptide(BNP)
