摘要
结直肠癌是最常见的消化道恶性肿瘤之一,根据肿瘤原发部位的不同,其发病率、发病机制、临床特征、生存预后、分子生物学特征及肠道菌群等方面均存在差异。本文主要针对结直肠癌原发部位的不同,阐述了相关分子生物学、肠道菌群以及免疫治疗的最新研究进展。不同的分子生物学特征导致了临床治疗反应的差异,从而导致了临床预后的差异,通过总结其中的规律,可以提高临床对结直肠癌中不同原发部位肿瘤的一系列不同特征的深刻认识,为提高及完善临床治疗提供进一步理论依据。
Colorectal cancer is one of the most common malignant tumors. According to the primary site of the tumor, the morbidity,etiology, molecular biological characteristics, clinical features, and gut microbiota of patients are different. This review focuses on the characteristics of colorectal cancer according to the tumor location and describes the newest discoveries in molecular biology, gut microbiota, and imunotherapy. Different molecular biological characteristics lead to differences in clinical treatment response, leading to differences in clinical prognosis. Deep understanding of the characteristics of colorectal cancer according to tumor location provides further theoretical basis for improving clinical treatment.
作者
阎伟
刘洋
魏云巍
Wei Yan;Yang Liu;Yunwei Wei(Department of Oncological and Laparoscopic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2018年第22期1155-1159,共5页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金面上项目(编号:81672351)资助~~
关键词
结直肠癌肿瘤
原发部位
流行病学
分子机制
肠道菌群
colorectal cancer
tumor primary location
epidemiology
molecular mechanism
gut microbiota
