摘要
目的分析患者血清及尿液中三酰甘油(triglyceride,TG)、血尿酸(uric acid,UA)以及血糖(glucose,Glu)、空腹血糖(fasting blood glucose,FBG)水平与肾结石成分和治疗后复发的关系,并探讨肾结石患者血清TG、UA和FBG水平、尿UA和GLU水平以及短期复发的危险因素。方法选取本院就诊的肾结石患者118例,分为一水草酸钙结石组、二水草酸钙结石组及其他组,随访1年,收集患者基本信息及血尿相关指标,分析患者血清及尿液中TG、UA以及Glu与肾结石成分和治疗后复发的关系。结果其他组结石成分类型患者主要表现为血清TG、UA及FBG绝对水平增高,且尿液中GLU表达最低。多因素Logistic回归分析发现饮酒过量、男性、BMI增高、血清UA水平增高及尿液UA水平增高、尿糖阳性均为一水草酸钙结石患者复发危险因素;BMI增高、男性、血清UA水平增高、FBG水平增高以及尿UA水平增高为二水草酸钙患者复发危险因素;二者共同的危险因素则包括:男性、血清及尿液的UA水平增加、FBG增高和尿糖阳性;而其他结石成分患者复发风险则在男性中更高,差异具有统计学意义(P <0. 05)。结论性别、血清UA、FBG及尿液UA、GLU高水平和含钙类结石成分的肾结石复发风险相关。
Objective The relationships between the serum and urine TG,UA,FBG and Glu levels and the renal calculus composition and recurrence after the treatment were analyzed.Methods 118 patients with renal calculi were selected and divided into the one calcium oxalate stone group,two calcium oxalate stone group and the other groups.The patients were followed up for 1 year.The basic information and hematuria index were collected during the followup.The relationships between the serum and urine TG,UA and Glu and the composition of renal calculi and recurrence after the treatment were analyzed.Results The serum levels of TG,UA and FBG were higher in patients with other types of stones,and GLU in the urine was the lowest.Multifactor logistic regression analysis showed that excessive drinking,male,increased BMI,higher serum UA level,higher urine UA content,and positive urine sugar were all the risk factors for the recurrence of calcium oxalate stones in the patients with one calcium oxalate stone.The increase of BMI,the increase of the level of UA,the increased level of FBG and the increase of the level of UA in the urine were risk factors for recurrence in two calcium oxalate stone group.The common risk factors across groups included the male,increased UA levels in serum and urine,increased FBG and positive urine sugar,while the risk of relapse in other lithiasis patients was higher in men(P<0.05).Conclusion Gender,the serum UA,FBG and urine UA and GLU levels are correlated with the renal stone recurrence risk.
作者
梁涛
燕东亮
刘园园
叶绪晓
李作为
田斌强
陈嵘
谢淼
LIANG Tao;YAN Dong-liang;LIU Yuan-yuan;YE Xu-xiao;LI Zuo-wei;TIAN Bin-qiang;CHEN Rong;XIE Miao(Department of Urology,Shanghai Sixth People′s Hospital East Affiliated to Shanghai University of Medicine&Health Sciences, Shanghai 201306,China;Department of Urology,Shanghai Sixth People′s Hospital,Shanghai 200233,China;Department of Urology,Affiliated Hospital of Binzhou Medical University,Binzhou 256603,China)
出处
《标记免疫分析与临床》
CAS
2018年第12期1767-1771,共5页
Labeled Immunoassays and Clinical Medicine
基金
上海市第六人民医院东院特色专业医学科(编号:2017022)
