摘要
目的探讨抑郁症和躯体形式障碍患者血清T_3、T_4以及TSH表达水平特征,并结合其临床特点分析彼此间的关系,为抑郁症和躯体形式障碍的预防以及控制该群体血清T_3、T_4以及TSH表达水平处于正常范围提供参考依据。方法于2017年5月至2018年1月采用定群抽样的方法选择研究对象,采用横断面调查的研究方法对入选人群开展不记名问卷调查,并结合受试对象的实验室结果进行进一步分析。结果本研究按照入选及排除标准共获得符合要求的观察对象220例。220例受试对象中判定为轻度抑郁的受试者37例(16.82%),判定为中度抑郁的受试者14例(6.36%),判定为重度抑郁的受试者14例(6.36%);判定为躯体形式障碍的受试者93例(42.27%);抑郁、躯体形式障碍严重程度均与血清TT_4、TT_3水平呈负相关,而与血清TSH水平正相关,均有P<0.05。结论抑郁症和躯体形式障碍患者的血清T_3、T_4以及TSH表达水平特征均与正常群体存在差异,且提示一定的病理特征,同时二者可以互为影响因素,因此改善患者的抑郁症和躯体形式障碍不仅具有精神病学层面的意义,同时对甲状腺功能的改善也可能具有潜在意义。
Objective To investigate the characteristics of serum T3,T4 and TSH expressions in patients with depression and somatoform disorders,and to analyze their relationship with clinical characteristics,so to provide potential solutions for preventing depression and somatoform disorders and to maintain the serum T3,T4 and TSH expression levels in the normal range.Methods From May 2017 to January 2018,the study population was selected using the method of cluster sampling,then the cross-sectional survey methods were used to conduct anonymous questionnaire surveys among the selected population,and the further analysis was performed based on the laboratory results of the subjects.Results A total of 220 subjects who met the requirements were included in this study according to the inclusion and exclusion criteria.Among them,37 were mild depression(16.82%),14 were moderate depression(6.36%)and 14 were severe depression(6.36%);93 cases(42.27%)were judged to be the somatic disorder,and the grade of depression and somatoform were negatively correlated with the level of serum TT4 and the level of serum TT3,while the level of serum TSH was positively correlated with the grade of depression and somatoform disorder,(all P<0.05).The level of somatoform disorder was negatively correlated with the serum TT4 level and serum TT3 level,while the serum TSH level was positively associated with the level of depression and somatoform disorder(all P<0.05).Conclusion The characteristics of serum T3,T4,and TSH levels in patients with depression and somatoform disorders are different from those in normal individuals,suggesting certain unique pathological features.Furthermore,they may be mutually influencing factors.Our study suggests that improving depression and somatoform of patients,not only have psychiatricbenifits,but also have potential implications for improving thyroid function.
作者
张川江
刘荣馨
杨培锋
贺金花
王娟
ZHANG Chuan-jiang;LIU Rong-xin;YANG Pei-feng;HE Jin-hua;WANG Juan(Department of Psychosomatic Health,Mental Health Center of Inner Mongolia Autonomous Region,Hohhot 010010,China;Department of Endocrine,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)
出处
《标记免疫分析与临床》
CAS
2018年第12期1804-1807,共4页
Labeled Immunoassays and Clinical Medicine
