摘要
目的:通过对南京医科大学附属儿童医院2013—2017年流感流行病学特征分析,为儿童流感的防控提供参考。方法:收集2013—2017年南京市儿童医院流感监测上报的流感样病例(influenza-like illness,ILI)资料和病原学检测结果,进行统计分析。结果:2013—2017年共上报ILI 184 488例,ILI就诊百分比(ILI%)为3.65%;采集标本5 643份,病毒分离阳性率为18.50%。各年份ILI%比较,差异有统计学意义(χ~2=5 682.98,P <0.001);病毒分离阳性率比较,差异也有统计学意义(χ~2=52.008,P <0.001)。流感在2013年呈单峰流行,流行优势菌株为季节性A(H3N2)型; 2014年呈双峰流行,流行优势菌株为新甲型H1N1和H3N2型; 2015年呈双峰流行,流行优势菌株为乙型BY系、H3N2型; 2016同样呈双峰流行,为新甲型H1N1、乙型BV系、H3N2交替流行; 2017年呈单峰流行,优势菌株为乙型BV系。不同年龄组间病毒分离阳性率比较,差异有统计学意义(χ~2=149.74,P <0.001)。不同性别病毒分离阳性率比较,差异无统计学意义(χ~2=0.134,P> 0.05)。结论:南京市儿童流感流行以H3N2型、新甲型H1N1、乙型流感病毒高峰交替出现,加强对幼托儿童、学生的疫苗接种有利于流感防控。
Objective:To study the epidemiological characteristics of influenza in Nanjing Children′s Hospital during 2013-2017,and provide references for the prevention and control of children′s influenza.Methods:Data of influenza-like illness(ILI)cases and etiological detection were collected and analyzed in Nanjing Children′s Hospital from 2013 to 2017.Results:A total of 184 488 ILI cases were reported from 2013 to 2017 and the percentage of influenza-like illness cases(ILI%)was 3.65%;a total of 5 643 specimens were collected and virus isolation positive rate was 18.50%.The ILI%was significantly different among different years(χ^2=5 682.98,P<0.001),and virus isolation positive rate was also significantly different among different years(χ^2=52.008,P<0.001).There was one peak in epidemic curves of influenza in year 2013,type A(H3N2)was the epidemic strain.There were two peaks in epidemic curves of influenza in year 2014,2015,2016,the epidemic strain was type A(H1N1)and type A(H3N2)in year 2014,type B(BY)and type A(H3N2)in year 2015,type A(H1N1),type B(BV)and type A(H3N2)in year 2016.There was one peak in epidemic curves of influenza in year 2017,type B(BV)was the epidemic strain.The positive rate of influenza virus was significantly different among the different age groups(χ^2=149.74,P<0.001),and had no statistically significant difference between male and female(χ^2=0.134,P>0.05).Conclusion:Children′s flu viruses in nanjing mainly type A(H3),type A(H1N1),and type B appeared alternately.Strengthen the vaccination of childcare children and students is conducive to the influenza prevention and control.
作者
周景
洪丽英
赵洋洋
黄敏
ZHOU Jing;HONG Liying;ZHAO Yangyang;HUANG MIN(Department of Prevention and Healthcare,Children′s Hospital of Nanjing Medical University,Nanjing 210008,China)
出处
《东南大学学报（医学版）》
CAS
2018年第6期1005-1009,共5页
Journal of Southeast University(Medical Science Edition)
基金
南京医科大学面上项目(2017NJMU071)
关键词
流感
监测
流行病学
儿童
influenza
monitoring
epidemiology
child
