摘要
目的:对比分析"傍刺阿是穴"结合音乐疗法与常规针刺结合艾司唑仑片治疗亚健康失眠的临床疗效。方法:符合纳入标准的60例亚健康失眠患者采用随机数表法分为治疗组和对照组,每组30例。治疗组给予"傍刺阿是穴"结合音乐疗法及艾司唑仑片治疗,对照组给予常规针刺结合艾司唑仑片治疗。观察两组治疗效果及治疗前后匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、γ-氨基丁酸(GABA)、血清P物质(substance P,SP)、神经肽Y(NPY)、肿瘤坏死因子α(TNF-α)和白细胞介素1(IL-1)的变化情况。结果:治疗组愈显率显著高于对照组(P <0. 05)。治疗组治疗后在睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能及PSQI总分方面均较治疗前改善明显(P <0. 05);对照组治疗后在入睡时间、睡眠时间、睡眠效率及PSQI总分方面较治疗前改善明显(P <0. 05);治疗前后评分差值方面,治疗组睡眠障碍、日间功能、PSQI总分与对照组比较差异显著(P <0. 05)。治疗后治疗组血清SP显著低于对照组(P <0. 05),NPY、GABA、IL-1、TNF-α显著高于对照组(P <0. 05)。结论:"傍刺阿是穴"结合音乐疗法在治疗亚健康失眠中具有较好的临床疗效,可显著改善患者日间功能及睡眠质量,对其体内相关神经递质、细胞因子等物质具有良性的调节作用,因此在临床应用及推广上价值颇高。
Objective: To compare and analyze the therapeutic effects of proximal needling Ashi points combined with musicotherapy and conventional acupuncture combined with Estazolam on sub-health insomnia. Methods: 60 patients who met the inclusion criteria were randomly divided into the treatment group(n=30) and the control group(n=30). The treatment group was treated with proximal needling Ashi points, musicotherapy, and Eszolam tablets. The control group was treated with routine acupuncture and Eszolam tablets. Curative effect, scores of Pittsburgh Sleep Quality Index(PSQI), and changes of γ-aminobutyric acid(GABA), substance P(SP), neuropeptide Y(NPY), tumor necrosis factor-α(TNF-α), and interleukin-1(IL-1) were observed before and after the treatment in the two groups. Results: The curative effect rate in the treatment group was significantly higher than that in the control group( P<0.05). After the treatment, the PSQI score and the serum level of SP in the treatment group were significantly lower than those in the control group( P<0.05);the levels of NPYA, GABA, IL-1, and TNF-α were significantly higher in the treatment group than those in the control group( P<0.05). Conclusion: Proximal needling Ashi points combined with musicotherapy has a better clinical effect on sub-health insomnia, it can significantly improve the daytime activity and the sleep quality of the patients, it has a significant positive effect on the related neurotransmitter and cytokines. Therefore, its clinical value of application and promotion is quite high.
作者
李崖雪
刘梦佳
张洋
曹丹娜
赵旭
刘潇
LI Yaxue;LIU Mengjia;ZHANG Yang;CAO Danna;ZHAO Xu;LIU Xiao(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China;Heilongjiang University of Chinese Medicine, Harbin 150040, China)
出处
《中医药信息》
2019年第1期29-33,共5页
Information on Traditional Chinese Medicine
基金
黑龙江省自然科学基金面上项目(No.H2015033)
黑龙江中医药大学科研基金项目(No.201704)
哈尔滨市科技创新人才研究专项资金青年后备人才项目(No.2017RAQXJ180)
