摘要
目的:探讨通窍活血汤加减联合鼠神经生长因子对青中年突发性耳聋的临床疗效,并分析其血液流变学变化。方法:选取符合纳入标准的青中年突发性耳聋患者92例,随机分为对照组及研究组,各46例。对照组给予鼠神经生长因子及西医常规治疗,研究组在对照组基础上给予通窍活血汤加减治疗。对比治疗前后血液流变学指标及纯音测听(PTA)阈值,临床疗效和治疗期间不良反应发生情况。结果:两组治疗后纤维蛋白原、血浆黏度、全血低切黏度、全血中切黏度、全血高切黏度及红细胞压积均明显低于治疗前(P <0. 05),且研究组治疗后各项指标均明显低于对照组(P <0. 05);两组治疗后PTA阈值均明显低于治疗前(P <0. 05),且研究组治疗后明显低于对照组(P <0. 05);两组临床疗效等级分布比较有显著差异(P <0. 05),研究组总有效率(92. 45%,49/53)明显高于对照组(78. 85%,41/53)(P <0. 05);两组不良反应发生率无明显差异(P> 0. 05)。结论:通窍活血汤加减联合鼠神经生长因子可明显改善青中年突发性耳聋患者血液流变,降低纯音听阈,疗效显著,且不会增加不良反应,具有推广应用价值。
Objective: To investigate the clinical efficacy of Tongqiao Huoxue Decoction combined with mouse nerve growth factor on sudden deafness of young adults, and to analyze its influence to hemorheology. Methods: 92 cases of sudden deafness of young adults were randomly divided into the control group(n=46) and the study group(n=46). The control group was treated with mouse nerve growth factor and conventional western medication;on which basis, the study group was also treated with Tongqiao Huoxue Decoction. The hemorheology parameters and the threshold of pure tone audiometry(PTA) before and after the treatment and the clinical efficacy were compared in the two groups;also the incidences of adverse reactions during the treatment were observed. Results: The fibrinogen, plasma viscosity, whole blood low-shear viscosity, whole blood middle-shear viscosity, whole blood high-shear viscosity and hematocrit were all significantly lowered after the treatment in the two groups( P<0.05);the changes in the study group were more significant than those in the control group( P<0.05). The PTA threshold was significantly decreased after the treatment in the two groups( P<0.05);the decrease of the study group was more significant than that of the control group( P < 0.05). There was a significant difference between the two groups in terms of the grade distributions of clinical efficacy( P<0.05);the total effective rate of the study group was 92.45%(49/53), which was significantly higher than 78.85%(41/53) of the control group( P<0.05). There was no significant difference between the two groups in terms of the incidences of adverse reactions( P >0.05). Conclusion: Tongqiao Huoxue Decoction combined with mouse nerve growth factor can obviously improve the hemorheology of the young adults patients with sudden deafness and reduce the PTA, with the remarkable curative effect without increasing the adverse reactions, which is worthy of popularization and application.
作者
陈伟
胡中南
童钊君
李湘宇
周磊颢
刘文君
CHEN Wei;HU Zhongnan;TONG Zhaojun;LI Xiangyu;ZHOU Leihao;LIU Wenjun(Changde First TCM Hospital, Changde 415000, China)
出处
《中医药信息》
2019年第1期45-48,共4页
Information on Traditional Chinese Medicine
关键词
通窍活血汤
鼠神经生长因子
青中年
突发性耳聋
临床疗效
血液流变学
Tongqiao Huoxue Decoction
Mouse nerve growth factor
Young adult
Sudden deafness
Clinical efficacy
Hemorheology
