摘要
早期经皮冠状动脉介入及溶栓治疗能及时地开放闭塞的冠状动脉,使缺血的心肌得到再灌注,挽救心肌梗死患者的生命。但部分心肌梗死患者由于微血管阻塞、大量氧自由基产生等原因,再灌注后会诱导心肌细胞损伤,加重心脏的功能障碍和结构改变。沉默信息调节因子3(SIRT3)是Sirtuin蛋白家族的成员,具有一定的心脏保护作用。最近的研究表明,SIRT3可能在心肌缺血再灌注损伤(MIRI)中对心肌细胞起到一定的保护作用。该文将对SIRT3在MIRI中保护作用机制的研究进展作一综述。
Early percutaneous coronary intervention and thrombolytic therapy can timely treat the coronary arterial occlusion, offer reperfusion to the ischemic myocardium and save the lives of patients with myocardial infarction. Nevertheless, due to microvascular obstruction and a large quantity of oxygen free radicals, reperfusion may induce cardiomyocyte injury and aggravate cardiac dysfunction and structural changes in certain patients with myocardial infarction. Sirtuin 3(SIRT3) is a member of the sirtuin protein family, and exerts certain cardioprotective effect. Recent studies have demonstrated that SIRT3 exerts a protective effect on the development of myocardial ischemia-reperfusion injury(MIRI). In this review, the research progress on the mechanism of SIRT3 in MIRI was summarized.
作者
覃秋语
徐彤彤
武琦
赵位昆
Qin Qiuyu;Xu Tongtong;Wu Qi;Zhao Weikun(Medical Care Ward, Affiliated Hospital of Guilin Medical University,Guilin 541001, China)
出处
《新医学》
2019年第1期7-10,共4页
Journal of New Medicine
基金
国家自然科学基金资助项目(81760861)
桂林市科学研究与技术开发计划项目(20160226-1-1)
