摘要
目的:探讨糖皮质激素联合特布他林治疗慢阻肺急性加重期的临床效果。方法:选取2015年10月～2017年10月我院收治的慢阻肺急性加重期140例患者纳为研究群体,将其随机等分为2组,称为实验组和常规组,每组有患者70例,治疗方案以糖皮质激素为变量,实验组在常规组应用特布他林治疗上,再增添糖皮质激素治疗,比较两组治疗效果,观察两组治疗前后FVC、FEV1、6MWT等肺功能指标,记录患者治疗前后血气指标对比。结果:实验组治疗效果十分优秀,治疗有效率高达98.57%,而常规组治疗效果表现中等,有效率仅为78.57%,显而易见,实验组治疗效果更优;实验组方案对FVC、FEV1、6MWT等肺功能调节效果更突出,各项数据更优秀,说明该方案对各项指标调节效果更优;应用本组方案后,血气状况均得到改善,其中,实验组改善效果更为显著,PaCO_2、PaO_2等指标状况更优,P<0.05,组间差异具有统计学意义。结论:糖皮质激素与特布他林联合治疗慢阻肺急性加重期,能够给予患者更优治疗效果,患者肺功能回复进展更快,血气指标改善效果更为明显。
Objective:To investigate the clinical effect of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods:140 patients with acute exacerbation of chronic obstructive pulmonary disease in our hospital from October 2015 to October 2017 were divided into 2 groups,which were divided into experimental group and routine group.There were 70 patients in each group.The treatment regimen was treated with glucocorticoid as the variable.The experimental group added sugar to the routine group and added sugar.The treatment effect of corticosteroid was compared between the two groups.The lung function indexes such as FVC,FEVI and 6MWT were observed before and after treatment in the two groups,and the blood gas indexes were recorded before and after the treatment.Results:the therapeutic effect of the experimental group was excellent,the effective rate of treatment was up to 98.57%,and the effect of the conventional group was moderate and the efficiency was only 78.57%.Obviously,the effect of the experimental group was better.The effect of the experimental group on FVC,FEV 1,6MWT and other lung functions was more outstanding.After the application of this group,the blood gas status was improved,and the experimental group improved significantly,PaCO2,PaO2 and other indicators were significantly better(P﹤0.05).Conclusion:The combination of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease can give patients better therapeutic effect.The recovery of pulmonary function is faster and the improvement of blood gas index is more obvious.
作者
尚胜君
苏振轩
SHANG Sheng-jun;SU Zhen-xuan(Department of Internal Medicine 4,Xuchang County People's Hospital,Xuchang Henan 461000,China;Department of Internal Medicine,Xuchang Hospital of Traditional Chinese Medicine,Xuchang Henan 461000,China)
出处
《药品评价》
CAS
2019年第1期50-52,共3页
Drug Evaluation
关键词
慢阻肺急性加重期
糖皮质激素
特布他林
联合
Chronic Exacerbation of Chronic Obstructive Pulmonary Disease
Glucocorticoid
Terbutaline
Combination
