生长抑素联合奥美拉唑对重症急性胰腺炎血清炎性因子与肠道黏膜屏障功能的影响被引量：29

Effect of somatostatin combined with omeprazole on serum inflammatory factors and intestinal mucosal barrier function in severe acute pancreatitis

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摘要目的:探讨生长抑素联合奥美拉唑对重症急性胰腺炎血清炎性因子与肠道黏膜屏障功能的影响。方法:选取本院收治的重症急性胰腺炎患者并随机分为两组,对照组接受常规+奥美拉唑治疗,联合组接受常规+生长抑素+奥美拉唑治疗,持续1周。对比两组入院即刻、治疗1周后血清中炎症因子、趋化因子、肠道黏膜屏障功能指标含量的差异。结果:治疗1周后,两组血清中IL-1β、IL-8、IL-18、hs-CRP、MCP-1、FKN、CINC、D-Lactate、DAO、Endotoxin、FABP的含量均明显降低,且观察组治疗后的血清IL-1β、IL-8、IL-18、hs-CRP、MCP-1、FKN、CINC、D-Lactate、DAO、Endotoxin、FABP含量低于对照组。结论:生长抑素联合奥美拉唑治疗重症急性胰腺炎可有效缓解机体炎症反应程度并保护肠道黏膜屏障功能。 Objective: To investigate the effect of somatostatin combined with omeprazole on serum inflammatory factors and intestinal mucosal barrier function in severe acute pancreatitis. Methods: Patients with severe acute pancreatitis who were treated in Zigong Third People's Hospital between August 2014 and December 2017 were chosen and divided into two groups by random number table method. Control group received conventional + omeprazole treatment, combined group received conventional + somatostatin + omeprazole treatment and the treatment lasted for 1 week. The differences in serum levels of inflammatory factors, chemokines and intestinal mucosal barrier function indexes were compared between the two groups immediately after admission and after 1 week of treatment. Results: After 1 week of treatment, serum IL-1β, IL-8, IL-18, hs-CRP, MCP-1, FKN, CINC, D-Lactate, DAO, Endotoxin and FABP levels of both groups significantly decreased and serum IL-1β, IL-8, IL-18, hs-CRP, MCP-1, FKN, CINC, D-Lactate, DAO, Endotoxin and FABP levels of combined group were significantly lower than those of control group ( P<0.05). Conclusion: Somatostatin combined with omeprazole therapy for severe acute pancreatitis can effectively alleviate the inflammatory response and protect the intestinal mucosal barrier function.

作者廖长福邹世斌 LIAO Chang-fu;ZOU Shi-bin(Intensive Care Unit, Zigong Third People's Hospital, Zigong 643020, Sichuan, China)

机构地区自贡市第三人民医院重症医学科

出处《海南医学院学报》 CAS 2018年第24期2133-2136,共4页 Journal of Hainan Medical University

基金四川省医学会课题项目(160187)~~

关键词重症急性胰腺炎生长抑素奥美拉唑炎性因子肠道黏膜屏障功能 Severe acute pancreatitis Somatostatin Omeprazole Inflammatory factor Intestinal mucosal barrier function

分类号 R576 [医药卫生—消化系统]