摘要
肝纤维化是各种慢性肝功能损伤保护性的代偿反应,是以细胞外基质生成增多和降解减少为主要表现、大量细胞外基质在肝内沉积为主要特征的病理过程。肝纤维化是慢性肝病向肝硬化和肝癌转变的必经过程。Rho-ROCK信号转导通路参与多种细胞生理活动,主要通过调节肝星状细胞的收缩和迁移参与肝纤维化的形成。肝星状细胞的活化在肝纤维化形成中具有重要作用,其活化后分泌的细胞外基质(extracellular matrixc,ECM)是肝纤维化形成的物质基础。本文通过对Rho-ROCK信号转导通路和肝星状细胞的生物学特性以及Rho-ROCK信号转导通路对肝星状细胞的调控进行综述,以期为肝纤维化的防治提供新方向。
Liver fibrosis is a compensatory response to chronic liver function damage.It is a pathological process characterized by the increase of extracellular matrix and the decrease of degradation,and the deposition of a large amount of extracellular matrix in liver.Liver fibrosis is a necessary process for the transformation of chronic liver disease to liver cirrhosis and liver cancer.The Rho-ROCK signaling transduction pathway is involved in many cell physiological activities,and it is mainly through regulating the contraction and migration of hepatic stellate cells to participate in the formation of liver fibrosis.The activation of hepatic stellate cells plays an important role in the formation of liver fibrosis and the extracellular matrix secreted by activated hepatic stellate cells is the material basis for its formation.The biological characteristics of Rho-ROCK signaling transduction pathway and hepatic stellate cells and the regulation of Rho-ROCK signaling transduction pathway on hepatic stellate cells were reviewed in this paper,in order to provide a new direction for the prevention and treatment of liver fibrosis.
作者
郑洋
王嘉孺
王佳慧
刘露露
傅品悦
赵铁建
ZHENG Yang;WANG Jia-ru;WANG Jia-hui;LIU Lu-lu;FU Pin-yue;ZHAO Tie-jian(Graduate School,Guangxi University of Traditional Chinese Medicine,Nanning 530000,China;Nursing College,Guangdong Medical University,Dongguan 523000,Guangdong Province,China;Department of Physiology,School of Basic Medicine,Guangxi University of Traditional Chinese Medicine,Nanning 530000,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2018年第4期38-42,共5页
Chinese Journal of Liver Diseases：Electronic Version
基金
国家自然科学基金项目(81460682
81660705
81403189)
广西中医药大学研究生校级重点课题(YCSZ2018013)
