摘要
目的:系统评价妊娠早期单纯甲状腺过氧化物酶抗体阳性对妊娠晚期甲状腺功能异常及不良妊娠结局的影响。方法:计算机检索Pubmed、Embase、中国生物医学文献数据库、维普中文科技期刊数据库、万方数据库和中国知网,收集妊娠早期单纯甲状腺过氧化物酶抗体阳性者妊娠晚期甲状腺功能异常及不良妊娠结局的病例对照研究,筛选及纳入文献,提取相关资料及数据,采用Review Manager 5.1软件进行meta分析。结果:共纳入18篇文献进行研究,结果显示妊娠早期单纯甲状腺过氧化物酶抗体阳性与流产、胎儿宫内发育迟缓和妊娠晚期甲功异常具有相关性(OR=3.35、1.64、3.23。)结论:妊娠早期单纯甲状腺过氧化物酶抗体阳性可增加流产、胎儿宫内发育迟缓和妊娠晚期甲状腺功能异常的风险。
Objective: To systematically evaluate the relationship between isolated thyroid peroxidase antibody positive of pregnant women in the first trimester pregnancy and their thyroid function and pregnancy outcomes in the third trimester pregnancy. Methods: Databases, such as CNKI, VIP, WanFang, PubMed and EMbase were electronically searched to collected case control studies about the association between isolated thyroid peroxidase antibody positive in the first trimester pregnancy and their thyroid function and pregnancy outcomes in the third trimester pregnancy. The articles which matched the including standard were selected, and the related information and data were extracted. Then meta analysis was performed by Review Manager 5.1 software. Results: A total of 18 articles were included in the meta analysis. The results of meta analysis showed that, isolated thyroid peroxidase antibody positive in the first trimester pregnancy was related to the increased risks of abortion, fetal intrauterine growth retardation, and abnormal thyroid function ( OR =3.35, 1.64, 3.23). Conclusion: Isolated thyroid peroxidase antibody positive in the first trimester pregnancy maybe increase the risks of abortion, fetal intrauterine growth retardation, and abnormal thyroid function in the third trimester pregnancy.
作者
岳欣欣
付洋
YUE Xinxin;FU Yang(He Medical Unversity of Liaoning Province, Shenyang, Liaoning Province, 110163;Northern District General Hospital)
出处
《中国计划生育学杂志》
2018年第12期1147-1154,1159,共9页
Chinese Journal of Family Planning
基金
2017年辽宁省自然科学基金项目(NO.20170540944)
关键词
过氧化物酶抗体
妊娠
甲状腺功能
不良妊娠结局
META分析
病例对照
Isolated thyroid peroxidase antibody positive
Pregnancy
Thyroid function
Adverse pregnancy outcomes
Meta analysis
Case control study
