摘要
目的探讨血清降钙素原(PCT)在老年医院获得性肺炎中耐药菌和敏感菌中的差异及应用价值。方法选取2015年2月—2018年5月该院接诊的75例老年医院获得性肺炎患者为研究对象,均取空腹静脉血检测患者PCT、白细胞(WBC)、超敏C反应蛋白(hs-CRP)水平,比较不同痰培养结果 (多重耐药菌株组26例,广泛耐药菌株组20例,敏感菌组29例)和不同疾病程度(重症30例,非重症35例)患者血清PCT、WBC、hs-CRP水平差异。结果广泛耐药菌株组PCT水平为(5.25±0.60)ng/mL,高于多重耐药菌株组、敏感菌组的(3.83±0.37)、(0.74±0.21)ng/mL,差异有统计学意义(P<0.05);多重耐药菌株组与广泛耐药菌株组hs-CRP水平分别为(50.36±3.70)、(52.27±4.56)mg/L,均高于敏感菌组的(30.65±2.76)mg/L,差异有统计学意义(P<0.05);3组WBC水平以及多重耐药菌株组、广泛耐药菌株组hs-CRP水平比较,差异无统计学意义(P>0.05);重症组PCT水平为(3.95±0.63)ng/mL,高于非重症组的(1.41±0.55)ng/mL,差异有统计学意义(P<0.05);重症组WBC、hs-CRP水平与非重症组比较,差异无统计学意义(P>0.05)。结论与WBC、hs-CRP相比,PCT可更好的判断老年医院获得性肺炎疾病严重程度、区分耐药菌与敏感菌;早期鉴别PCT水平变化,可早期评估、诊断患者病情,指导临床使用抗生素,降低耐药菌株的发生率,改善患者预后。
Objective To study the difference and application value of serum procalcitonin in the drug resistant bacteria and sensitive bacteria of community acquired pneumonia in the gastric hospital.Methods 75 cases of patients with community acquired pneumonia in the gastric hospital from February 2015 to May 2018 were selected as the research objects,and the PCT,WBC,hs-CRP levels of patients were tested,and the serum PCT,WBC,hs-CRP levels of patients of the different sputum culture results including 26 cases in the multi drug resistant strain,20 cases in the extensively drug-resistant strain group and 29 cases in the sensitive bacteria group and patients in different diseases degrees(30 severe cases and 35 non-severe cases)were compared.Results The PCT level in the extensively drug-resistant strain was higher than that in the multi drug resistant strain group and in the sensitive group[(5.25±0.60)ng/mL vs(3.83±0.37),(0.74±0.21)ng/mL],and the differences were statistically significant(P<0.05),and the hs-CRP level in the multi drug resistant strain group and in the extensively drug-resistant strain group were respectively(50.36±3.70),(52.27±4.56)mg/L,which were higher than those in the sensitive bacteria group(30.65±2.76)mg/L,and the differences were statistically significant(P<0.05),and the difference in the WBC level and hs-CRP level between the multi drug resistant strain group and the extensively drug-resistant strain group was not statistically significant(P>0.05),and the PCT level in the severe group was higher than that in the non-severe group[(3.95±0.63)ng/mL vs(1.41±0.55)ng/mL],and the difference was statistically significant(P<0.05),and the differences in the WBC and hs-CRP levels between the severe group and non-severe group were not statistically significant(P>0.05).Conclusion The PCT can better determine the severity of acquired pneumonia in the gastric hospital than WBC,hs-CRP,which can distinguish the drug resistant bacteria and sensitive bacteria,identify the changes of PCT level in the early stage,conduct the early evaluation and diagnosis of disease of patients,guide the clinical use of antibiotics,reduce the incidence rate of drug-resistant strains and improve the prognosis of patients.
作者
王林仙
WANG Lin-xian(Geriatrics Department,Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu Province,212000 China)
出处
《世界复合医学》
2018年第5期80-82,共3页
World Journal of Complex Medicine
关键词
老年医院获得性肺炎
降钙素原
耐药菌
敏感菌
Community acquired pneumonia in the gastric hospital
Calcitonin
Drug resistant bacteria
Sensitive bacteria
