摘要
目的探讨利拉鲁肽联合清热祛浊胶囊对2型糖尿病患者血管内皮的保护作用。方法将初诊120例肥胖2型糖尿病患者随机分为对照组、利拉鲁肽组、清热祛浊胶囊组及联合组各30例。4组患者均根据个体情况给予糖尿病饮食处方控制、健康教育及个体化运动指导等基础治疗,在此基础上,对照组给予二甲双胍肠溶片治疗,利拉鲁肽组在对照组治疗基础上联合利拉鲁肽治疗,清热祛浊胶囊组在对照组治疗基础上联合清热祛浊胶囊治疗,联合组在对照组治疗基础上联合利拉鲁肽和清热祛浊胶囊治疗,4组均连续治疗12周。观察4组患者治疗12周后体质量指数(BMI)、血糖、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、血脂、内皮素-1(ET-1)、一氧化氮(NO)水平变化情况,超声测定肱动脉血流介导的内皮依赖性血管舒张功能(FMD),统计4组患者治疗过程中药物不良反应发生情况。结果治疗12周后,4组患者的BMI、血糖、HbA1c、血脂、HOMA-IR、ET-1、NO、FMD均比治疗前有明显改善(P均<0. 05),而且联合组患者上述指标改善程度比其他3组更明显(P均<0. 05);联合组患者药物不良反应发生率明显低于其他3组(P均<0. 05)。结论利拉鲁肽联合清热祛浊胶囊对初诊肥胖2型糖尿病患者具有更好的降糖、降脂及改善胰岛素分泌的作用,并且具有明显的保护血管内皮功能作用。
Objective It is to investigate the protective effect of liraglutide combined with Qingre Quzhuo capsule on vascular endothelium in patients with type 2 diabetes mellitus.Methods 120 patients with obese type 2 diabetes were randomly divided into control group,liraglutide group,Qingre Quzhuo capsule group and combination group,each group had 30 cases.All the patients in the 4 groups were given basic treatments such as diet prescription control,health education and individualized exercise guidance according to individual conditions.On the basis of this,the control group was treated with metformin enteric-coated tablets,the liraglutide group was treated with liraglutide based on the control group,Qingre Quyu capsule group was treated with Qingre Quyu capsule on the basis of the control group,and the combination group was treated with liraglutide and Qingre Quyu capsule on the basis of the control group,and the four groups were treated continuously for 12 weeks.The changes of body mass index(BMI),blood glucose,glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA-IR),blood lipids,endothelin-1(ET-1),and nitric oxide(NO)were observed after 12 weeks of treatment,brachial artery blood flow-mediated endothelium-dependent vasodilation(FMD)was detected by ultrasound,and the incidence of adverse drug reactions during the treatment of the four groups were recorded.Results After 12 weeks of treatment,BMI,blood glucose,HbA1c,blood lipids,HOMA-IR,ET-1,NO,and FMD were significantly improved in the four groups(P<0.05),and the improvements of the above indicators in the combination group were more obvious than those in the other three groups(P<0.05);the incidence of adverse drug reactions in the combination group was significantly lower than that in the other three groups(P<0.05).Conclusion Liraglutide combined with Qingre Quzhuo capsule has better hypoglycemic,lipid-lowering and insulin-improving effects and has obvious protective effect on vascular endothelial function in patients with newly diagnosed obese type 2 diabetes.
作者
刘爱茹
马凌云
于文霞
杨振华
李秀贞
LIU Airu;MA Lingyun;YU Wenxia;YANG Zhenhua;LI Xiuzhen(Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,Hebei,China)
出处
《现代中西医结合杂志》
CAS
2019年第2期138-141,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
沧州市科技计划项目(162302170)
