摘要
目的研究探讨四红祛斑汤联合脊柱梳理治疗气滞血瘀型黄褐斑患者的临床疗效。方法选取2015年1月—2017年1月丹东市230医院收治的气滞血瘀型黄褐斑患者78例为研究对象,按随机数字表法分为观察组和对照组,每组39例。其中观察组采用四红祛斑汤联合脊柱梳理治疗,对照组采用常规西药治疗。于治疗后对两组患者的疗效和治疗安全性进行综合评价。结果 (1)两组临床总有效率比较,差异有统计学意义(χ2=5.186,P=0.023),观察组高于对照组。(2)治疗后两组患者的皮肤含水量和皮肤弹性比较,差异有统计学意义(t=8.298和6.651,均P=0.000),观察组高于对照组。(3)治疗后两组患者的血清一氧化氮(NO)、超氧化物歧化酶(SOD)水平比较,差异有统计学意义(t=4.585和7.389,均P=0.000),观察组患者NO水平低于对照组患者,SOD则高于对照组。(4)两组患者治疗后不良反应发生率比较,差异有统计学意义(χ2=5.014,P=0.025),观察组低于对照组。结论四红祛斑汤联合脊柱梳理治疗气滞血瘀型黄褐斑的临床疗效更佳,可改善患者的皮损面积和皮肤颜色,提高黄褐斑患者的血清SOD活性,降低血清NO水平,具有抗氧化作用,且治疗的安全性好,有较高的临床应用价值。
Objective To investigate the clinical effect of Sihongqubantang combined with spine carding treatment on qi stagnation and blood stasis type chloasma.Methods Totally 78 cases of qi stagnation and blood stasis type chloasma treated in 230 hospital of Dandong city from January 2015 to January 2017 were selected.They were divided into observation group (n=39) and control group (n=39) by random number table method.The observation group received Sihongqubantang combined with spinal carding treatment,the control group received routine western medicine.After treatment,the efficacy and treatment safety of the two groups were evaluated.Results ① The total effective rate of the two groups was statistically significant different (χ^2=5.186,P=0.023),the clinical efficacy of the observation group was higher than that of the control group.② The skin moisture and elasticity in observation group were statistically significant higher than those of control group after treatment (t=8.298 and 6.651,all P=0.000).③ Serum nitric oxide (NO) level in observation group was lower than control group,while superoxide dismutase (SOD) level in observation group was higher than control group after treatment (t=4.585 and 7.389,all P=0.000).④ The incidence of adverse reactions after treatment in observation group was statistically significant lower than control group (χ^2=5.014,P=0.025).Conclusion The clinical effect of Sihongqubantang combined with spine carding treatment on qi stagnation and blood stasis type chloasma is remarkable,which can significantly improve lesion area and the skin color of the patients,improve the activity of serum SOD,decrease the serum level of NO and be antioxidant.The treatment is safe and has high clinical application value.
作者
韩秀萍
郭强
Xiu-ping Han;Qiang Guo(Department of Medical and Cosmetic Technology,Eastern Liaoning University,Dandong,Liaoning 118000,China;Department of Dermatology,230 Hospital of Dandong City,Dandong,Liaoning 118000,China)
出处
《中国现代医学杂志》
CAS
2019年第1期99-102,共4页
China Journal of Modern Medicine
关键词
黑变病
四红祛斑汤/中草药
脊柱梳理
气滞血瘀
melanosis
sihongqubantang/drugs,Chinese herbal
spinal carding
qi stagnation and blood
