摘要
目的研究妊娠期甲状腺功能减退患者运用左旋甲状腺激素,对促甲状腺激素、游离三碘甲状腺原氨酸、游离甲状腺激素水平的影响。方法选择2015年3月～2018年2月我院收治的64例妊娠期甲状腺功能减退患者,按照患者意愿分为对照组(30例)和观察组(34例),对照组拒绝使用任何药物,观察组采取左旋甲状腺激素进行治疗,对比两组治疗结果。结果用药前两组TSH、FT3及FT4水平差异无显著性(P>0.05),用药后两组均明显改善,但观察组各指标水平均优于对照组(P<0.05);观察组并发症发生率14.71%明显低于对照组36.67%(P<0.05);观察组新生儿不良症状发生率为5.88%,明显低于对照组的23.33%(P<0.05);观察组治疗有效率为94.12%,明显高于对照组的73.33%(P<0.05)。结论左旋甲状腺素运用于妊娠期甲状腺功能减中效果明显,有效改善甲状腺激素水平,保障母婴安全,避免并发症产生,为预后提供保障。
Objective To study the effects of levothyroid hormone on the levels of thyroid stimulating hormone,free triiodothyronine ammonia and free thyroid hormone in patients with hypothyroidism during pregnancy.Methods 664 patients with hypothyroidism during pregnancy from March 2015 to February 2018 were enrolled in our hospital.64 patients were divided into control group (30 cases) and observation group (34 cases) according to the patient's will.In the control group,30 patients refused to use any drugs,and 34 patients in the observation group were treated with L-thyroid hormone.Comparisons of treatment results between the two groups.Results There was no significant difference in the levels of TSH,FT3 and FT4 between the two groups before and after treatment(P>0.05),but the levels of each index in the observation group were better than those in the control group(P<0.05);the incidence of complications in the observation group was 14.71% lower than 36.67% in the control group (P<0.05);the incidence of adverse neonatal symptoms in the observation group was 5.88%,which was significant.The effective rate of the observation group was 94.12%,which was significantly higher than that of the control group(73.33%,P<0.05).Conclusion L-thyroxine can effectively improve the level of thyroid hormone,ensure the safety of mothers and infants,avoid complications,and provide a guarantee for prognosis.
作者
刘薇
LIU Wei(Department of Obstetrics and Gynecology,Lianyungang Oriental Hospital,Lianyungang 222042,China)
出处
《中国现代医生》
2018年第34期15-18,共4页
China Modern Doctor
