摘要
目的通过对比分析病毒性脑炎急性期症状性痫性发作演变为脑炎后癫痫临床发生率和影响因素,为治疗脑炎后癫痫提供理论依据。方法选取自2013年1月-2017年1月本院接诊的78例脑炎急性期症状性痫性发作患者为研究对象,对参与研究的患者进行随访,记录患者行为、思维变化等精神状态、影像学检查结果、服用抗癫痫药物情况等指标,采用Logistic回归分析对脑炎急性期症状性痫性发作演变为脑炎后癫痫症状的相关因素进行分析。结果 78例脑炎急性期症状性痫性发作患者中,30例患者在随访过程中发展为脑炎后癫痫患者,发生率为38.46%,其中21例患者在随访6个月内发展为脑炎后癫痫,占发展为脑炎后癫痫患者比率为70%;病毒性脑炎急性期出现癫痫持续症状是影响病毒性脑炎急性期症状性痫性发作发展为脑炎后癫痫的独立危险因素(P <0.05),病毒性脑炎急性期后继续服用抗癫痫药物是影响病毒性脑炎急性期症状性痫性发作发展为脑炎后癫痫的保护性因素(P <0.05)。结论病毒性脑炎急性期症状性痫性发作发展为脑炎后癫痫的临床发生率较高,病毒性脑炎急性期出现癫痫持续症状的患者应继续服用抗癫痫药物。
Objective The incidence of post-encephalitic epilepsy(PEE)and its influencing factors in patients with viral encephalitis at acute symptomatic seizures were compared and analyzed to provide a theoretical basis for the treatment of post-encephalitic epilepsy.Methods 78 patients with acute symptomatic seizures(AESS)were collected from January 2013 to January 2017.The mental state of the patients′behavior and changes of thoughts,imaging findings,taking anti-epileptic drugs and other indicators were collected.With Logistic regression,the factors affected patients with AESS to be PEE were explored.Results 30 developed into PEE among the 78 patients with AESS,with PEE incidence of 38.46%.21 patients developed into PEE within 6 months of follow-up,with PEE incidence of 70%;viral encephalitis in the acute phase was an independent risk factor for the development of post-encephalitic epilepsy(P<0.05).The continued use of antiepileptic drugs after the acute phase of viral encephalitis was a protective factor which influence the development of post-encephalitic epilepsy(P<0.05).Conclusion The clinical incidence of post-encephalitic epilepsy in patients with viral encephalitis at acute symptomatic seizures is high,and patients with viral encephalitis at acute symptomatic seizures should continue take antiepileptic drugs after acute encephalitis.
作者
刘娟
冯志伟
郭明升
刘保强
申真
赵姗姗
LIU Juan;FENG Zhiwei;GUO Mingsheng;LIU Baoqiang;SHEN Zhen;ZHAO Shanshan(Department of Neurology,General Hospital of Jizhong Energy Fengfeng Group Co.,Ltd.,Handan,Hebei Province,056200;Department of orthopedics,general hospital,Jizhong energy peak group co.,Ltd.,Handan,Hebei,056200)
出处
《新疆医科大学学报》
CAS
2019年第1期100-103,107,共5页
Journal of Xinjiang Medical University
基金
河北省卫生计生委医学科学研究重点项目(20181744)
关键词
病毒性脑炎
脑炎后癫痫
发生率
症状性痫性发作
viral encephalitis
post-encephalitis epilepsy
incidence
symptomatic seizures
