摘要
目的:探讨91例卵巢交界性肿瘤(BOT)的临床病理特征及复发影响因素Cox回归分析。方法:回顾性分析本院在2012年4月-2016年6月收治的91例BOT患者临床资料,根据病理类型不同将其分为浆液性卵巢交界性肿瘤(SBOT)组(50例)与黏液性卵巢交界性肿瘤(MBOT)组(41例)。对比分析两组患者的各临床病理特征,采用Cox回归模型探讨影响患者复发的相关因素。结果:患者出院后平均随访时间(24.91±8.64)个月,出现9例(9.89%)复发,无死亡;两组患者的发病年龄、累及侧卵巢、微浸润及腹膜种植等临床病理特征比较,差异均无统计学意义(P>0.05),SBOT组患者肿瘤最大直径小于MBOT组(P<0.05);两组的肿瘤形态比较,差异有统计学意义(P<0.05);SBOT组的肿瘤标志物CA199含量低于MBOT组,CA125含量高于MBOT组(P<0.05);两组的FIGO分期比较,差异无统计学意义(P>0.05)。通过Log-rank检验单因素分析发现病理类型、手术方式、术前肿瘤标志物水平、术后化疗、肿瘤最大直径等因素与患者肿瘤的复发无关(P>0.05);而FIGO分期、微浸润和腹膜组织种植与复发有关(P<0.05);采用多元逐步Cox对有意义的影响因素进行回归分析,结果显示微浸润、腹膜组织种植、FIGO分期(Ⅲ期)均是卵巢交界性肿瘤患者复发的独立影响因素,差异均有统计学意义(P<0.05)。结论:经分析发现FIGO分期及微浸润组织、腹膜种植均属于BOT的复发危险因素。
Objective:To investigate the clinicopathological features of 91 cases of borderline ovarian tumors(BOT) and Cox regression analysis of its recurrence factors.Method:The clinical data of 91 BOT patients admitted to our hospital from April 2012 to June 2016 were retrospectively analyzed.Patients were divided into serous borderline ovarian tumors(SBOT) group(n=50) and mucinous borderline ovarian tumors(MBOT) group(n=41) according to the different pathological types.The clinical and pathological characteristics of the two groups were compared and analyzed.Then the Cox regression model was used to explore the related factors affecting the recurrence of the patients.Result:The average follow-up time was(24.91±8.64)months,during that period,9 cases(9.89%) had recurrence without death.The clinicopathological features including the onset age,ovarian involvement,microinfiltration and peritoneal implantation had no differences between the two groups(P>0.05).The maximum diameter of tumor in the SBOT group was less than that in the MBOT group(P<0.05).The tumor morphology of the two groups had statistical difference(P<0.05).The content of tumor marker CA199 in SBOT group was lower than that in MBOT group,and the content of CA125 was higher than that in MBOT group(P<0.05).Comparison of FIGO staging between the two groups showed no significant difference(P>0.05).The single-factor analysis by log-rank showed that the factors such as pathological type,surgical method,preoperative tumor marker level,postoperative chemotherapy,maximum tumor diameter and so on were not related to the recurrence of patients’ tumors(P>0.05);FIGO stage,microinvasion and peritoneal tissue implantation were associated with recurrence(P<0.05).Multivariate stepwise Cox regression analysis showed that microinvasive infiltration,peritoneal tissue implantation, and FIGO staging(stage Ⅲ) were independent influencing factors for recurrence of BOT(P<0.05).Conclusion:Analysis shows that the FIGO staging,microinvasive tissue and peritoneal implantation are all risk factors for recurrence of BOT.
作者
戴伟超
郑志群
DAI Weichao;ZHENG Zhiqun(Affiliated Union Hospital of Fujian Medical University,Fuzhou 350001,China)
出处
《中国医学创新》
CAS
2018年第35期40-44,共5页
Medical Innovation of China
关键词
卵巢交界性肿瘤
病理特征
复发因素
COX回归分析
Borderline ovarian tumors
Clinicopathological feature
Recurrence factors
Cox regression analysis
